TITLE

Molecular Diagnostics of Human Papillomavirus

AUTHOR(S)
Arney, Ashley; Bennett, Katie M.
PUB. DATE
September 2010
SOURCE
Laboratory Medicine;Sep2010, Vol. 41 Issue 9, p523
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the United States. This review summarizes the molecular testing methods currently in use for the detection and genotyping of HPV DNA and discusses potential future approaches. Summary: There are more than 100 different types of HPV, which are separated into low- and high-risk categories, depending on clinical presentation. Low-risk types can cause warts, while high-risk types are associated with cervical cancer. The available methods for HPV detection and genotyping include both target and signal amplification techniques. Conclusion: Molecular diagnostic methods allow for the identification of the many unique types of high-risk HPV, which can lead to better diagnoses and treatment plans for patients. Use of these diagnostic techniques requires consideration of the consensus guidelines for management of women with normal and abnormal cervical screens, as well as consideration of assay clinical sensitivity and diagnostic utility.
ACCESSION #
70267952

 

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