Postmortem trucut transnasal brain biopsy in the diagnosis of encephalitis

Sudarsanam, Thambu David; Chacko, Geeta; David, Rani Diana
July 2008
Tropical Doctor;Jul2008, Vol. 38 Issue 3, p163
Academic Journal
Diagnosing encephalitis is often difficult with a definitive diagnosis being reached at best in only 40% of cases. This clinical condition is associated with a high morbidity and mortality. A brain biopsy is the gold standard for the diagnosis of this disease. However, this procedure is rarely done, resulting in the cause of death being largely speculative. We propose a simple procedure for postmortem brain biopsy through the transnasal transcribriform route that will possibly be more acceptable to clinicians and relatives alike due to lack of external disfigurement, relative ease of the procedure and economy of time and manpower. This could also prove to be of immense benefit in an epidemic of encephalitis, especially in remote areas.


Related Articles

  • Antworten zu den Fragen zu «klinische Autopsie» aus PRAXIS Nr. 2.  // Praxis (16618157);1/29/2014, Vol. 103 Issue 3, p175 

    No abstract available.

  • Pitfalls associated with the diagnosis of herpes simplex encephalitis: Commentary. Sellner, Johann // Journal of Neurosciences in Rural Practice;Apr-Jun2013, Vol. 4 Issue 2, p179 

    The author discusses the argument of I. Vachalová, L. Kyavar, J. G. Heckmann regarding the pitfalls associated with herpes simplex encephalitis (HSE) diagnosis. He states that mortality in HSE remains high despite the improvement in HSE prognosis. He mentions that the cases presented by the...

  • Verbal autopsy can consistently measure AIDS mortality: a validation study in Tanzania and Zimbabwe. Lopman, B.; Cook, A.; Smith, J.; Chawira, G.; Urassa, M.; Kumogola, Y.; Isingo, R.; Ihekweazu, C.; Ruwende, J.; Ndege, M.; Gregson, S.; Zaba, B.; Boerma, T. // Journal of Epidemiology & Community Health;Apr2010, Vol. 64 Issue 4, p11 

    Background Verbal autopsy is currently the only option for obtaining cause of death information in most populations with a widespread HIV/AIDS epidemic. Methods With the use of a data-driven algorithm, a set of criteria for classifying AIDS mortality was trained. Data from two longitudinal...

  • Causes of death in patients with rheumatoid arthritis from 1971 to 1991 with special reference to autopsy. Koivuniemi, Riitta; Paimela, Leena; Leirisalo-Repo, Marjatta // Clinical Rheumatology;Dec2009, Vol. 28 Issue 12, p1443 

    Rheumatoid arthritis (RA) patients have premature mortality, mostly attributed to cardiovascular diseases (CVDs). We studied causes of death (CoDs) and contribution of autopsy to them in RA patients treated at a single hospital responsible for primary to tertiary RA treatment in Helsinki. In...

  • Population based mortality and quality of death certification in progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome). Nath, U.; Thomson, R.; Wood, R.; Ben-Shlomo, Y.; Lees, A.; Rooney, C.; Burn, D. // Journal of Neurology, Neurosurgery & Psychiatry;Apr2005, Vol. 76 Issue 4, p498 

    Objective: To estimate the mortality of progressive supranuclear palsy (PSP) and to assess the quality of death certification in patients with PSP who died in England and Wales.Methods: An analysis was conducted of ICD-9 (International Classification of Diseases,...

  • Case Definitions, Diagnostic Algorithms, and Priorities in Encephalitis: Consensus Statement of the International Encephalitis Consortium. Venkatesan, A.; Tunkel, A. R.; Bloch, K. C.; Lauring, A. S.; Sejvar, J.; Bitnun, A.; Stahl, J-P.; Mailles, A.; Drebot, M.; Rupprecht, C. E.; Yoder, J.; Cope, J. R.; Wilson, M. R.; Whitley, R. J.; Sullivan, J.; Granerod, J.; Jones, C.; Eastwood, K.; Ward, K. N.; Durrheim, D. N. // Clinical Infectious Diseases;Oct2013, Vol. 57 Issue 8, p1114 

    We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.Background....

  • Surveillance of injury-related deaths: medicolegal autopsy rates and trends in Finland. Lunetta, Philippe; Lounamaa, Anne; Sihvonen, Sanna // Injury Prevention (1353-8047);Aug2007, Vol. 13 Issue 4, p282 

    Medicolegal autopsies are a vital tool for obtaining reliable injury mortality data. In Finland, medicolegal autopsies have increased from 13.6% of all deaths in 1970 to 23.8% in 2004. In fact, medicolegal autopsies are performed in 87.2% of all unintentional injury deaths, 98.3% of homicides...

  • Acute Febrile Encephalopathy in Children and Predictors of Mortality. BOKADE, C. M.; GULHANE, R. R.; BAGUL, A. S.; THAKRE, S. B. // Journal of Clinical & Diagnostic Research;Aug2014, Vol. 8 Issue 8, p9 

    Background: Incidence of acute febrile encephalopathy (AFE) is high in children and associated with high mortality and sequela. Limited data is available about predictors of mortality in children of AFE from central India. Aim: To study the predictors of mortality in children of AFE. Methods:...

  • Clinical Significance of Human Metapneumovirus in Refractory Status Epilepticus and Encephalitis: Case Report and Review of the Literature. Vehapoglu, Aysel; Turel, Ozden; Uygur Sahin, Turkan; Kutlu, Nurettin Onur; Iscan, Akın // Case Reports in Neurological Medicine;11/18/2015, p1 

    Encephalitis is a complex neurological disease that is associated with significant morbidity and mortality, and the etiology of the disease is often not identified. Human metapneumovirus (hMPV) is a common cause of upper and lower respiratory tract infections in children. Few reports are...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics