Method to predict the chance of developing a male profile out of mixtures of male and female DNA

Laberke, Patrick; Grossenbacher, Rahel; Hausmann, Roland; Balitzki, Beate
January 2012
International Journal of Legal Medicine;Jan2012, Vol. 126 Issue 1, p157
Academic Journal
In forensic examination it is a standard to take vaginal swabs from victims of sexual assault for further molecular genetic analysis. Laboratories then are usually confronted with mixtures of lots of female and only a small amount of male DNA. Nowadays it is possible to work with specific Y chromosomal markers after DNA extraction by differential lysis. The determined ratio of autosomal DNA and Y chromosomal DNA can be used to identify the possibility of generating a male profile in these samples.


Related Articles

  • Mutation rates at 16 Y-chromosome STRs in the South China Han population. Weng, Weixia; Liu, Hong; Li, Shuanglin; Ge, Jianye; Wang, Huijun; Liu, Chao // International Journal of Legal Medicine;Mar2013, Vol. 127 Issue 2, p369 

    Nine hundred eighteen DNA-confirmed father-son pairs were typed for 16 Y-chromosomal short tandem repeat (Y-STR) markers by AmpFLSTR® Yfiler™ PCR Amplification kit. In a total of 15,606 allele transmissions, 36 mutations were detected. The average mutation rate across all 16 Y-STR...

  • Belarusians: ethnogeny and connection with other Slavonic peoples from DNA genealogy perspective. Roghanskiy, Igor; Tsyibovskiy, Iosif; Bogachova, Anna; Kotova, Svetlana; Zabavskaya, Tatyana; Shahnyuk, Natalia; Klyosov, Anatoliy // Science & Innovations;Mar2013, Vol. 121 Issue 3, p55 

    A series of 1086 Y-chromosomal 20-marker haplotypes from Belarus was analyzed in terms of DNA genealogy. It was found that these haplotypes belong to Eastern Slavic (R1a1), North-West Slavic (I1), South Slavic (I2), and South Baltic (N1c1) tribes, and detailed analysis of history of the tribes...

  • Admixture Estimates for Caracas, Venezuela, Based on Autosomal, Y-Chromosome, and mtDNA Markers. Martínez, Helios; Rodríguez-Larralde, Alvaro; Izaguirre, Mary Helen; Castro De Guerra, Dinorah // Human Biology;Apr2007, Vol. 79 Issue 2, p201 

    The present Venezuelan population is the product of admixture of Amerindians, Europeans, and Africans, a process that was not homogeneous throughout the country. Blood groups, short tandem repeats (STRs), mtDNA, and Y-chromosome markers have been used successfully in admixture studies, but few...

  • Y-chromosomal diversity of the Valachs from the Czech Republic: model for isolated population in Central Europe. Ehler, Edvard; Vaněk, Daniel; Stenzl, Vlastimil; Vančata, Václav // Croatian Medical Journal;Jun2011, Vol. 52 Issue 3, p358 

    Aim To evaluate Y-chromosomal diversity of the Moravian Valachs of the Czech Republic and compare them with a Czech population sample and other samples from Central and South-Eastern Europe, and to evaluate the effects of genetic isolation and sampling. Methods The first sample set of the...

  • Clinical consequences of microdeletions of the Y chromosome: the extended Münster experience. Simoni, Manuela; Tüttelmann, Frank; Gromoll, Jörg; Nieschlag, Eberhard // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Feb2008, Vol. 16 Issue 2, p289 

    A total of 3179 patients were screened for Y-chromosome microdeletions and 821 patients for partial AZFc deletions. Thirtynine Y-chromosomal microdeletions were found (2.4% of men with <1 x 106/ml spermatozoa): two AZFa, two AZFb, one AZFbc, one partial AZab, one partial AZFb+c and 32 AZFc...

  • Farming shaped dog evolution, study finds. Bailey, Pat // Western Farm Press Exclusive Insight;2/28/2013, p6 

    The article discusses research on Western dogs. Researchers at the University of California, Davis, School of Veterinary Medicine calculated the mutation rate of genetic markers on the Y chromosome in 100 Australian dingoes. Through this process, they estimated the time when dogs of Eurasia and...

  • The scale and nature of Viking settlement in Ireland from Y-chromosome admixture analysis. McEvoy, Brian; Brady, Claire; Moore, Laoise T.; Bradley, Daniel G. // European Journal of Human Genetics;Dec2006, Vol. 14 Issue 12, p1288 

    The Vikings (or Norse) played a prominent role in Irish history but, despite this, their genetic legacy in Ireland, which may provide insights into the nature and scale of their immigration, is largely unexplored. Irish surnames, some of which are thought to have Norse roots, are paternally...

  • Multiple origins of Tibetan Y chromosomes. Yaping Qian; Binzhi Qian; Bing Su; Jiankun Yu; Yuehai Ke; Zhengtao Chu; Lei Shi; Daru Lu; Jiayou Chu; Li Jin // Human Genetics;Apr2000, Vol. 106 Issue 4, p453 

    The genetic origin of Tibetans was investigated using Y chromosome markers. A total of three populations were studied, two from central Tibet speaking central Tibetan and one from Yunnan speaking Kham. Two dominant paternal lineages (>80%) were identified in all three populations with one...

  • A case of an infertile male with a small supernumerary marker chromosome negative for M-FISH and containing only heterochromatin. Wei Wang; Yali Hu; Haiyan Zhu; Jie Li; Ruifang Zhu; Ya-ping Wang // Journal of Assisted Reproduction & Genetics;May2009, Vol. 26 Issue 5, p291 

    Aim To describe the case of a 32-year-old infertile male with small supernumerary marker chromosome (sSMCs) in 80% of peripheral lymphocytes. Methods G-banding, C-banding, STRP analysis, M-FISH and molecule diagnosis of Y-chromosomal microdeletions were performed to determine the origin of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics