Rapid tranquillization agents for severe behavioural disturbance: a survey of African psychiatrists' prescription patterns

James, Bawo Onesirosan
January 2011
Tropical Doctor;Jan2011, Vol. 41 Issue 1, p49
Academic Journal
Guidelines on the use of rapid tranquillizers for severe behavioural disturbance have changed over the last six decades. This survey reports aminimal change in the prescription patterns among psychiatrists sampled from Africa. Parenteral chlorpromazine and diazepam are still commonly prescribed, the least being intramuscular lorazepam, olanzapine and promethazine. Respondents indicated that drug availability was more likely than prescription preference or cost to influence their choices. They were also equally concerned about the tranquillizer's side effects, its ability to provide rapid and sustained sedation and its ability to calma patient while awaiting psychiatric assessment.


Related Articles

  • Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/ 5-HT4 ligands. Bell, Rob; Duke, Aaron A.; Gilmore, Paula E.; Page, Deaglan; Bègue, Laurent // Scientific Reports;1/24/2014, p1 

    The present study examined the effects of administering selective 5-HT antagonists and agonists to rats tested in the elevated zero-maze (EZM) model of anxiety. The EZM paradigm has advantages over the elevated plus-maze (EPM) paradigm with respect to measuring anxiety, yet has been utilized...

  • Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents: Comparison with diazepam and buspirone. Griebel, G.; Perrault, Ghislaine; Sanger, David J. // Psychopharmacology;1998, Vol. 138 Issue 1, p55 

    Abstract The present series of experiments compared the behavioral effects of the novel non-peptide CRF antagonist CP-154,526 with those of diazepam and the 5-HT[sub 1A] receptor partial agonist buspirone in classical animal models of anxiety including conflict tests (punished lever pressing and...

  • Sensitivity of the fear-inhibited light reflex to diazepam. Bitsios, P.; Szabadi, E.; Bradshaw, C. M. // Psychopharmacology;1998, Vol. 135 Issue 1, p93 

    Abstract We have shown previously that pupil diameter increases and the amplitude of the pupillary light reflex is reduced when subjects are under threat of an aversive event (electric shock), and that light reflex amplitude correlates negatively with subjective anxiety. We have suggested that...

  • Genotypic Differences Between C57BL/6 and A Inbred Mice in Anxiolytic and Sedative Actions of Diazepam. Garrett, Kennon M.; Niekrasz, Iwona; Haque, Dewan; Parker, K. Michael; Seale, Thomas W. // Behavior Genetics; 

    The role of genotype in susceptibility to the behavioral actions of benzodiazepines is not well characterized. To develop a model for such studies, we have characterized the anxiolytic and sedative activities of diazepam in C57BL/6J and A/J inbred mice. C57BL/6J mice were more responsive than...

  • Effect of the neuroactive steroid α-THDOC on staircase test behavior in mice. Pick, C. G.; Peter, Yakov; Terkel, Joseph; Gavish, Moshe; Weizman, Ronit // Psychopharmacology;1996, Vol. 128 Issue 1, p61 

    This study examined the effect of the neuroactive steroid 3α, 5α-tetrahydrodeoxycorticosterone (α-THDOC) as compared to the benzodiazepines diazepam and midazolam and the barbiturate phenobarbital on the number of rearing events and the number of steps ascended in the mouse staircase...

  • Effects of benzodiazepine agonists on punished responding in pigeons and their relationship with clinical doses in humans. Kleven, M. S.; Koek, Wouter // Psychopharmacology;1999, Vol. 141 Issue 2, p206 

    Abstract Anxiolytic drugs generally produce anticonflict effects in both pigeons and rats, although relatively few anxiolytics have been examined in the pigeon and the procedure has not been as completely validated as the rat model. In this study, we examined the antipunishment effects of a...

  • Anxiolytic activity of aqueous extract of fruits of Trichosanthes dioica. ROXB. Bhadoriya, Sandeep Singh; Dixit, P. V.; Raghuvashi, Bhoopendra; Mangal, Ankit; Mandoriya, Narendra // Journal of Pharmacy Research;2012, Vol. 5 Issue 2, p1057 

    The present study was undertaken to evaluate the anxiolytic activity of aqueous extract of Trichosanthes dioica. Roxb(Family: Cucurbitaceae). The anxiolytic activity was evaluated by Elevated plusmaze, behavior models. The efficacy of the extract (100 and 500 mg/kg) was compared with the...

  • Pharmacological evaluation of anxiolytic property of aqueous root extract of Cymbopogon citratus in mice. Arome, David; Enegide, Chinedu; Fidelis Ameh, Solomon // Chronicles of Young Scientists;Jan-Jun2014, Vol. 5 Issue 1, p33 

    Aim: This study was designed to evaluate the anxiolytic property of aqueous root extract of Cymbopogon citratus in mice. Materials and Methods: In this study, stress induced hyperthermia (SIH), elevated plus maze (EPM) and open field experimental models were employed. Results: In SIH model, the...

  • Dialar.  // Royal Society of Medicine: Medicines;2002, p197 

    This article offers information on dialar, a proprietary, prescription-only preparation of the benzodiazepine diazepam. It can be used as an anxiolytic in the short-term treatment of anxiety, as a hypnotic to relieve insomnia, as an anticonvulsant and antiepileptic for status epilepticus and for...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics