TITLE

Validation of a Specific Health-related Quality of Life Instrument in a Large Cohort of Patients with Psoriasis: The QualiPso Questionnaire

AUTHOR(S)
Quintard, Bruno; Constant, Aymery; Bouyssou-Gauthier, Marie-Laure; Paul, Carle; François Truchetet; Thomas, Pierre; Guiguen, Yves; Taieb, Alain
PUB. DATE
November 2011
SOURCE
Acta Dermato-Venereologica;2011, Vol. 91 Issue 6, p660
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of this study was to develop and validate a standardized tool designed to assess health-related quality of life (HRQoL) in a large cohort of French patients with psoriasis, the QualiPso Questionnaire. A draft questionnaire was developed based on a literature review, followed by one-to-one interviews of 50 patients with psoriasis conducted by trained psychologists. The interview transcripts were analysed, after which 56 items were retained and validated in a cohort of 569 patients. Four QualiPso subscales were derived from factor analysis. The first factor encompasses disturbances of social life, a key factor in HRQoL among psoriasis patients (Cronbach's alpha coefficient: α = 0.948). The second factor assesses the impact of psoriasis on mental health (α = 0.932). The third factor reflects concerns related to treatment outcomes (α = 0.873), and the fourth factor is related to skin symptoms (α = 0.772). The subscales are related but distinct, accounting for 60% of the common variance. In conclusion, the QualiPso questionnaire provides a reliable and valid measure of a patient's psychosocial well-being in relation to psoriasis. It also measures the impact of concerns related to treatment outcomes and skin symptoms, which have not been addressed previously by HRQoL research on psoriasis.
ACCESSION #
70200328

 

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