Effects of occupational exposure to styrene on expression of adhesion molecule on leukocytes

Jahnová, E; Tulinská, J; Weissová, S; Dušinská, M; Fuortes, L
May 2002
Human & Experimental Toxicology;May2002, Vol. 21 Issue 5, p235
Academic Journal
Styrene is an indispensable chemical extensively used in plastic and synthetic rubber industries. Styrene is known to produce various types of hepatotoxic, neurotoxic, and genotoxic effects. Styrene may be immunotoxic by both direct and indirect mechanisms. Measurement of adhesion molecules is a new tool for the investigation of immune system modulation. The aim of this study was to evaluate the association of the expression of the adhesion molecules CD11a, CD11b, CD18, CD54, CD49d, and CD62L in white blood cells and levels of soluble adhesion molecules ICAM-1 and L-selectin in serum with occupational exposure to styrene. Analyses by flow cytometry revealed elevated levels of most of the assessed adhesion molecules on surfaces of lymphocytes, monocytes, and granulocytes. Expression of the adhesion receptor antigens CD11a on lymphocytes, CD11b on monocytes, and CD18 on granulocytes were unaffected. Workers exposed to styrene had decreased concentrations of sICAM-1 and no changes in concentrations of sL-selectin. Styrene exposure appears to increase activation of the immune system and alter leukocyte adherence. This interaction is a critical first step in immune stimulation and leukocyte- endothelial interaction.


Related Articles

  • Analysis of local and systemic inflammatory responses induced by polymicrobial peritonitis in mice. Fr�de, T�nia Silvia; Ferreira, Silvia Ines Alejandra Cordoba Pires; Medeiros, Yara Santos // Mediators of Inflammation;Oct2001, Vol. 10 Issue 5, p237 

    BACKGROUND: Abdominal sepsis induces a local production of proinflammatory mediators that may trigger both septic shock and organ-system dysfunction. Aims: The present study analyzed exudation, cell migration, and CD11a and CD18 subset cells of both local and systemic responses induced by fecal...

  • Adhesion molecules in cutaneous immunity. Fuhlbrigge, Robert; Weishaupt, Carsten // Seminars in Immunopathology;2007, Vol. 29 Issue 1, p45 

    Skin serves a vital role, providing protection from the broad array of pathogens present in our environment. In addition to the passive barrier functions of the skin, mammals have evolved a robust and versatile surveillance and rapid response system for recognition and elimination of invading...

  • Micropatterned surfaces for controlling cell adhesion and rolling under flow. Divya Nalayanda; Mahendran Kalukanimuttam; David Schmidtke // Biomedical Microdevices;Apr2007, Vol. 9 Issue 2, p207 

    Abstract  Cell adhesion and rolling on the vascular wall is critical to both inflammation and thrombosis. In this study we demonstrate the feasibility of using microfluidic patterning for controlling cell adhesion and rolling under physiological flow conditions. By controlling the width of...

  • Recent Progress in the Design of Selectin Inhibitors. Chhabra, Siri Ram; Rahim, Aisyah S. Abdul; Kellam, Barrie // Mini Reviews in Medicinal Chemistry;Nov2003, Vol. 3 Issue 7, p679 

    The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis-x (sLe-x). Current development of small molecule based inhibitors of this...

  • ICAM-1 expression and leukocyte accumulation in inner stripe of outer medulla in early phase of ischemic compared to HgCl2 -induced ARF. De Greef, Kathleen E.; Ysebaert, Dirk K.; Persy, Veerle; Vercauteren, Sven R.; De Broe, Marc E. // Kidney International;May2003, Vol. 63 Issue 5, p1697 

    ICAM-1 expression and leukocyte accumulation in inner stripe of outer medulla in early phase of ischemic compared to HgCl2 -induced ARF. Background. After ischemia/reperfusion (I/R), as well as after toxic insults, there is significant infiltration of leukocytes in the kidney. It is well known...

  • LFA-1 Contributes to Signal I of T-Cell Activation and to the Production of Th1 Cytokines. Varga, Georg; Nippe, Nadine; Balkow, Sandra; Peters, Thorsten; Wild, Martin K.; Seeliger, Stephan; Beissert, Stefan; Krummen, Mathias; Roth, Johannes; Sunderkötter, Cord; Grabbe, Stephan // Journal of Investigative Dermatology;Apr2010, Vol. 130 Issue 4, p1005 

    The β2 integrins are important for both transendothelial migration of leukocytes and T-cell activation during antigen presentation. In T cells, triggering of leukocyte functional antigen-1 (LFA-1) is required for full activation and T-helper (Th)1/Th2 differentiation. We used CD18-deficient...

  • ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease. Rijcken, E.; Krieglstein, C.F.; Anthoni, C.; Laukoetter, M.G.; Mennigen, R.; Spiegel, H.U.; Senninger, N.; Bennett, C.F.; Schuermann, G. // Gut;Oct2002, Vol. 51 Issue 4, p529 

    Background: Recruitment of circulating cells to the inflamed intestine is modulated by adhesion molecules expressed on the surface of both leucocytes and endothelial cells. Aims: The objective of this study was to test whether 2'-O-methoxyethyl chimeric antisense oligonucleotides directed...

  • Mucosal vascular addressin cell adhesion molecule-1 is expressed outside the endothelial lineage on fibroblasts and melanoma cells. Leung, Euphemia; Kanwar, Rupinder K; Kanwar, Jagat R; Krissansen, Geoffrey W // Immunology & Cell Biology;Aug2003, Vol. 81 Issue 4, p320 

    Summary Mucosal vascular addressin cell adhesion molecule-1 (MAdCAM-1) is predominantly expressed on high endothelial venules in inflamed tissues where it assists with leucocyte extravasation. Here we report that MAdCAM-1 has the potential to be more widely expressed outside the endothelial cell...

  • Leukocyte functional antigen 1 lowers T cell activation thresholds and signaling through cytohesin-1 and Jun-activating binding protein 1. Perez, Omar D.; Mitchell, Dennis; Jager, Gina C.; South, Sharon; Murriel, Chris; McBride, Jacqueline; Herzenberg, Lee A.; Kinoshita, Shigemi; Nolan, Garry P. // Nature Immunology;Nov2003, Vol. 4 Issue 11, p1083 

    Leukocyte functional antigen 1 (LFA-1), with intercellular adhesion molecule ligands, mediates T cell adhesion, but the signaling pathways and functional effects imparted by LFA-1 are unclear. Here, intracellular phosphoprotein staining with 13-dimensional flow cytometry showed that LFA-1...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics