Radioiodine tracers as useful tools in studies of thyrotoxic effects of exogenous bromide and perchlorate ions

Pavelka, Stanislav
February 2012
Journal of Radioanalytical & Nuclear Chemistry;Feb2012, Vol. 291 Issue 2, p405
Academic Journal
With the use of I and I radionuclides, we followed the effects of exogenous bromide and perchlorate ions on the metabolism of iodine and of thyroid hormone in the rat. The presumed thyrotoxic effects of bromide and perchlorate have been confirmed and quantified. Correct assay conditions for the radiometric determination of the enzyme activity of thyroid peroxidase (TPO) have been established. The use of the adapted radiometric assay revealed a divergent influence of bromide and perchlorate ions on the TPO activity in the rat thyroids. Excessive bromide exerted a biphasic effect, depending on the extent of bromide intake in the animals. In contrast, in all the rats that were administered with high amounts of perchlorate were found elevated TPO activities.


Related Articles

  • Use of INAA and ICP-MS for the assessment of trace element mass fractions in adult and geriatric prostate. Zaichick, Vladimir; Zaichick, Sofia // Journal of Radioanalytical & Nuclear Chemistry;Aug2014, Vol. 301 Issue 2, p383 

    The variation with age of the mass fraction of 54 trace elements (Ag, Al, As, Au, B, Be, Bi, Br, Cd, Ce, Co, Cr, Cs, Dy, Er, Eu, Fe, Ga, Gd, Hf, Hg, Ho, Ir, La, Li, Lu, Mn, Mo, Nb, Nd, Ni, Pb, Pd, Pr, Pt, Rb, Re, Sb, Sc, Se, Sm, Sn, Ta, Tb, Te, Th, Ti, Tl, Tm, U, Y, Yb, Zn, and Zr) in intact...

  • Determination of I in cement-solidified radwastes using neutron activation. Kuo, C.; Tsai, T.; Chiang, A.; Chang-Liao, K.; Chao, J. // Journal of Radioanalytical & Nuclear Chemistry;Oct2013, Vol. 298 Issue 1, p465 

    The purpose of this study is to develop a neutron activation method to determine trace amounts of I in cement-solidified radwastes. The radwaste samples were alkaline fused using KOH and then I and iodine carrier were chemically separated by solvent extraction before and after neutron...

  • Neutron activation analysis of trace elements in Japanese hormesis cosmetics. Furuta, E.; Nakahara, H.; Hatsukawa, Y.; Matsue, H.; Sakane, H. // Journal of Radioanalytical & Nuclear Chemistry;Dec2008, Vol. 278 Issue 3, p553 

    In Japan, cosmetics claiming hormesis effect are available through Internet. Although these cosmetics show the contents, they never mention the minor elements and radioactive sources. The existence of radioisotopes, however, was observed by measurements of the gamma-rays with a HPGe detector. In...

  • Determination of trace elements using multi-parameter coincidence spectrometry. Hatsukawa, Y.; Toh, Y.; Oshima, M.; Kimura, A.; Hosein Mahmudy Gharaie, M. // Journal of Radioanalytical & Nuclear Chemistry;Jan2007, Vol. 271 Issue 1, p43 

    In this study, sensitive trace element analyses were carried out without chemical separation by the combination of neutron activation analysis and multi-parameter coincidence spectroscopy. A long-lived radioisotope 129I in algae samples and iridium in geological samples were analyzed.

  • Installation of Kayzero-INAA standardization in the TNRC and its applications for trace elements determination in different materials. Abugassa, I. O.; Khrbish, Y. S.; Abugassa, S. O.; Ben Faid, N.; Bashir, A. T.; Sarmani, S. // Journal of Radioanalytical & Nuclear Chemistry;Jan2007, Vol. 271 Issue 1, p27 

    The paper focuses on the validation of the k 0-method of instrumental neutron activation analysis ( k 0-INAA) in the Tajura Nuclear Research Center (TNRC) via the analysis of several certified reference materials. The selected reference materials were: SRM 1572 Citrus Leaves, SRM 1575 Pine...

  • Development of the Procedure for Simultaneous Determination of Vanadium, Uranium and Manganese in Biological Materials Using RNAA. Repinc, Urška; Benedik, Ljudmila // Acta Chimica Slovenica;2008, Vol. 55 Issue 3, p653 

    Radiochemical neutron activation analysis (RNAA) for simultaneous determination of V, U and Mn at trace levels in biological materials is described. This method is based on short irradiation of the sample together with standards and sequential separations of the induced nuclides based on...

  • New technique for the determination of trace elements using multiparameter coincidence spectrometry. Hatsukawa, Y.; Toh, Y.; Oshima, M.; Hayakawa, T.; Shinohara, N.; Kushita, K.; Ueno, T.; Toyoda, K. // Journal of Radioanalytical & Nuclear Chemistry;Jan2003, Vol. 255 Issue 1, p111 

    Multiparameter coincidence g-ray spectrometry based on g-g coincidence is widely used in the field of nuclear structure studies, and has produced many succesful results. In this paper, feasibility of the method for neutron activation analysis of trace elements was studied. Particularly, a...

  • Low background counting at the LBNL low background facility. Thomas, K. J.; Smith, A. R.; Chan, Y. D.; Norman, E. B.; Wang, B. S.; Hurley, D. L. // AIP Conference Proceedings;Aug2013, Vol. 1549 Issue 1, p20 

    The Low Background Facility (LBF) at the Lawrence Berkeley National Laboratory (LBNL) in Berkeley, California provides low background gamma spectroscopy services to end-users in two unique facilities: locally within a carefully-constructed, low background laboratory space; and a satellite...

  • INAA application in the assessment of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn mass fraction in pediatric and young adult prostate glands. Zaichick, Vladimir; Zaichick, Sofia // Journal of Radioanalytical & Nuclear Chemistry;Dec2013, Vol. 298 Issue 3, p1559 

    The effect of age on trace element contents in intact prostate of 50 apparently healthy 0–30 year old males was investigated by neutron activation analysis with high resolution spectrometry of long-lived radionuclides. Mean values (M ± SΕΜ) for mass fraction (milligram...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics