TITLE

Radioiodine tracers as useful tools in studies of thyrotoxic effects of exogenous bromide and perchlorate ions

AUTHOR(S)
Pavelka, Stanislav
PUB. DATE
February 2012
SOURCE
Journal of Radioanalytical & Nuclear Chemistry;Feb2012, Vol. 291 Issue 2, p405
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
With the use of I and I radionuclides, we followed the effects of exogenous bromide and perchlorate ions on the metabolism of iodine and of thyroid hormone in the rat. The presumed thyrotoxic effects of bromide and perchlorate have been confirmed and quantified. Correct assay conditions for the radiometric determination of the enzyme activity of thyroid peroxidase (TPO) have been established. The use of the adapted radiometric assay revealed a divergent influence of bromide and perchlorate ions on the TPO activity in the rat thyroids. Excessive bromide exerted a biphasic effect, depending on the extent of bromide intake in the animals. In contrast, in all the rats that were administered with high amounts of perchlorate were found elevated TPO activities.
ACCESSION #
70119814

 

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