TITLE

Coartemether Induced Oxidative and Hepatic Damage in Plasmodium berghei Strain Anka Infected Mice

AUTHOR(S)
Anyasor, God'swill; Oyewole, Isaac; Ogunwenmo, Kayode; Ayowole, Adegoke
PUB. DATE
January 2012
SOURCE
Bulletin of Environmental Contamination & Toxicology;Jan2012, Vol. 88 Issue 1, p108
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study investigated the effect of coartemether on antioxidant and hepatotoxic biomarkers in Plasmodium berghei infected mice. Erythrocyte, hepatic and renal superoxide dismutase (2.71 ± 0.51; 1.96 ± 0.87; 2.84 ± 0.22 Units/mg protein respectively) and catalase (4.10 ± 0.10; 8.25 ± 1.24; 6.28 ± 0.11 Units/mg protein respectively) activities were significantly ( p < 0.05) elevated in 'parasitized and treated' (PnT) animals. Renal glutathione level (19.02 ± 0.20 μg/mL) was elevated in PnT animals. Glutathione S-transferase and malondialdehyde levels in hepatic (8.76 ± 0.49 μmol/min/mg; 527.23 ± 24.56 mmol/dL) and renal (3.35 ± 0.30 μmol/min/mg; 464.42 ± 59.13 mmol/dL) tissues were significantly high ( p < 0.05) in coartemether-treated animals alone. Plasma aspartate transferase (9.45 ± 3.59 U/L) and alanine transferase (5.78 ± 2.36 U/L) were high in PnT animals. Therefore, data indicates that in the presence of P. berghei, coartemether could alter the antioxidant status and induce hepatotoxic damage in mice.
ACCESSION #
70119461

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics