TITLE

Light and Scanning Electron Microscopic Studies on Chromium-Induced Anemia in a Murine Model

AUTHOR(S)
Ray, Rina; Sarkar, Nirmal
PUB. DATE
January 2012
SOURCE
Bulletin of Environmental Contamination & Toxicology;Jan2012, Vol. 88 Issue 1, p10
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Blood hemoglobin level, hematocrit value and erythrocyte count were reduced by 17.5, 17.4 and 15.9%, respectively, as compared to the controls, in Swiss mice treated intraperitoneally with hexavalent chromium (4 mg of potassium dichromate per Kg for 5 day per week) for 2 weeks. Echinocytic transformation of 33.8% erythrocytes, as revealed by both light and scanning electron microscopy, indicated the anemia to be hemolytic in nature. Leucopenia was apparent after 2 weeks (mean leucocyte count: 4.91 thousand c mm), but not 1 week of treatment (mean count: 6.43 thousand c mm), However, cytochemical studies indicated that chromium did not interfere with iron utilization for hemoglobin synthesis and also, did not cause denaturation of already synthesized hemoglobin. The study hints to the necessity of periodic monitoring of blood in workers of chromium-dependent tanneries of Kolkata, India.
ACCESSION #
70119459

 

Related Articles

  • IRON AND ANAEMIA IN THE NEONATAL MOUSE. Loh, T.T. // Australian Journal of Experimental Biology & Medical Science;Apr1975, Vol. 53 Issue 2, p167 

    Investigates the relationship between changes in the blood picture and iron metabolism in the neotonal mouse from birth to 20 days. Decrease of the hemoglobin, hematocrit and erythrocye count until the fifth day; Observation of the reversal of the counts until the 15th day; Similarity of the...

  • THE EFFECTS OF SWIMMING EXECISE AT 35°C WATER AND L-CARNITINE ON BLOOD CELLS OF MICE. Bekir, Çoksevim; Nazmi, Sarıtaş; Osman, Pepe; Hakan, Akdoğan; Serdar, Büyükipekçi // Ovidius University Annals, Series Physical Education & Sport/Sci;2010, Vol. 10 Issue 2, p154 

    Objective: We aimed to research the effects of swiming exercise that's water temparature35°C on blood cells of mice administred exhausted exercise. Methods and procedures: It was used 48 male mice of the type of balb/C in this research. Mice in research were divided into four groups consist...

  • Investigation of the influence of phenosan, ichphan-10, and melafen on red blood cells in vivo by atomic force microscopy. Binyukov, V.; Alekseeva, O.; Mil, E.; Albantova, A.; Fattachov, S.; Goloshchapov, A.; Burlakova, E.; Konovalov, A. // Doklady Biochemistry & Biophysics;Dec2011, Vol. 441 Issue 1, p245 

    The article presents a study on the influence of xenobiotics on the architectonics of red blood cells of mice through atomic force microscopy (AFM). It says that the drugs including melafen, ichphan-10, and phenosan were injected intraperitoneally to Balb mine and albino mice while AFM was used...

  • LEAD (Pb) INDUCED ANAEMIA IN SWISS MICE - LIGHT AND SCANNING ELECTRON MICROSCOPIC STUDIES. RINA RANI RAY; NIRMAL KUMAR SARKAR // International Journal of Pharma & Bio Sciences;Jan-Mar2013, Vol. 4 Issue 1, pB-22 

    Marked reductions in blood haemoglobin level, haematocrit value and erythrocyte count were observed after 1 and 2 weeks of intraperitoneal treatment of Swiss mice with lead nitrate (8 mg/Kg for 5 consecutive days per week), as compared to the respective controls. Echinocytic transformation of...

  • The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites. Lamb, Tracey J.; Langhorne, Jean // Malaria Journal;2008, Vol. 7, Special section p1 

    Background: Severe malarial anaemia is a major complication of malaria infection and is multifactorial resulting from loss of circulating red blood cells (RBCs) from parasite replication, as well as immune-mediated mechanisms. An understanding of the causes of severe malarial anaemia is...

  • Clinical Review: Microcytic anaemia. Barroso, Ana Filipa // GP: General Practitioner;5/21/2010, p49 

    The article presents information related to microcytic anemia. It is mentioned that a reduction in the total circulating number of red cells including haemoglobin concentration (Hb), the haematocrit (Hct) or the red blood cell count (RBC) is represented by anemia. It is stated that assessment of...

  • Primitive Sca-1 Positive BoneMarrow HSC in Mouse Model of Aplastic Anemia: A Comparative Study through Flowcytometric Analysis and Scanning Electron Microscopy. Chatterjee, Sumanta; Basak, Pratima; Das, Prosun; Das, Madhurima; Pereira, Jacintha Archana; Dutta, Ranjan Kumar; Chaklader, Malay; Chaudhuri, Samaresh; Law, Sujata // Stem Cells International;2010, p1 

    Self-renewing Hematopoietic Stem Cells (HSCs) are responsible for reconstitution of all blood cell lineages. Sca-1 is the "stem cell antigen" marker used to identify the primitive murine HSC population, the expression of which decreases upon differentiation to other mature cell types. Sca-1+...

  • Phytotherapeutic effects of Echinacea purpurea in gamma-irradiated mice. Abouelella, Amira M. K.; Shahein, Yasser E.; Tawfik, Sameh S.; Zahran, Ahmed M. // Journal of Veterinary Science;2007, Vol. 8 Issue 4, p341 

    Echinacea (E.) purpurea herb is commonly known as the purple coneflower, red sunflower and rudbeckia. In this paper, we report the curative efficacy of an Echinacea extract in γ-irradiated mice. E. purpurea was given to male mice that were divided into five groups (control, treated,...

  • Blackwater fever like in murine malaria. Rivera, Norma; Romero, Samanta; Menchaca, Ángeles; Zepeda, Armando; García, Luis; Salas, Gerardo; Romero, Laura; Malagón, Filiberto // Parasitology Research;Mar2013, Vol. 112 Issue 3, p1021 

    Blackwater fever (BWF) is the term used to designate the occurrence of hemoglobin pigments in the urine of patients infected with malaria parasites. BWF is more often associated with Plasmodium falciparum infection in man. The pathogenesis of BWF has not been explained satisfactorily. In the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics