Cystic Neutrophilic Granulomatous Mastitis

Renshaw, Andrew A.; Derhagopian, Robert P.; Gould, Edwin W.
September 2011
American Journal of Clinical Pathology;Sep2011, Vol. 136 Issue 3, p424
Academic Journal
Although granulomatous lobular mastitis is associated with gram-positive bacilli such as Corynebacterium, this association is not well known. We report 3 cases of mastitis caused by gram-positive bacilli. All 3 abscesses were suppurative with distinct enlarged cystic spaces in which rare gram-positive bacilli were identified. Two cases were also granulomatous. Cultures in all 3 cases were negative. All 3 patients recovered after biopsy and tetracycline-based therapy. Infection in the breast by gram-positive bacilli is associated with a distinct histologic pattern, including cystic spaces in the setting of neutrophilic/granulomatous inflammation that can be recognized and should prompt careful search for the organism within enlarged vacuoles.


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