TITLE

The Diagnostic Value of CD1d Expression in a Large Cohort of Patients With B-Cell Chronic Lymphoproliferative Disorders

AUTHOR(S)
Kotsianidis, Ioannis; Nakou, Evangelia; Spanoudakis, Emmanouil; Bouchliou, Irene; Moustakidis, Eleytherios; Miltiades, Paraskevi; Vadikolia, Chrisa M.; Szydlo, Richard; Karadimitris, Anastasios; Tsatalas, Costas
PUB. DATE
September 2011
SOURCE
American Journal of Clinical Pathology;Sep2011, Vol. 136 Issue 3, p400
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Immunophenotyping is indispensable in the differential diagnosis of B-cell chronic lymphoproliferative disorders (B-CLPDs). However, B-CLPDs often show overlapping immunophenotypic profiles and may be diagnostically challenging. CD1d is an HLA class I-like molecule that presents glycolipids to invariant natural killer T cells. Normal mature B cells constitutively express CD1d, but with the exception of some conflicting data, its expression in B-CLPDs is unknown. We demonstrate that in 222 B-CLPD cases, CD1d expression of less than 45% is strongly predictive of CLL (likelihood ratio, 32.3; specificity, 97.4%; sensitivity, 84.1%). In addition, CD1d showed significantly higher staining intensity in splenic marginal zone lymphoma compared with atypical hairy cell leukemia, lymphoplasmacytic lymphoma, and mantle cell lymphoma, thus allowing the discrimination of the former from the latter immunophenotypically overlapping B-CLPDs. It is important to note that in a given patient, CD1d expression on malignant B cells was similar between tissues and remained unaffected by disease stage and treatment status. Our findings strongly argue for the incorporation of CD1d into routine lymphoma panels.
ACCESSION #
70108911

 

Related Articles

  • Hairy cell leukemia with large cells: long disease course with adequate response to therapy. Sun, X; Amin, H M; Freireich, E J; Keating, M J; Kantarjian, H M; Koller, C A; O'Brien, S M; Giles, F; Albitar, M // Leukemia (08876924);Nov2004, Vol. 18 Issue 11, p1912 

    Presents several cases of hairy cell leukemia (HCL), a lymphoproliferative disorder associated with peripheral blood pancytopenia and leukemic infiltration of bone marrow and spleen. Natural history of HCL; Relationship of interferon alpha with possible development of the pulmonary embolism;...

  • Extranodal Castleman disease of the extremities: a case report and review of the literature. Eward, William; DeWitt, Suzanne; Brigman, Brian; Kontogeorgakos, Vasilios; Lagoo, Anand // Skeletal Radiology;Nov2014, Vol. 43 Issue 11, p1627 

    Castleman disease is a rare lymphoproliferative disorder of unknown etiology that most commonly presents as a mediastinal nodal mass or, in the extranodal form of the disease, a mass located in the mediastinum or retroperitoneum. It is exceptionally uncommon for Castleman disease to present in...

  • Defining origins of malignant B cells: a new circulating normal human IgM+D+ B-cell subset lacking CD27 expression and displaying somatically mutated IGHV genes as a relevant memory population. Weston-Bell, N.; Townsend, M.; Di Genova, G.; Forconi, F.; Sahota, S. S. // Leukemia (08876924);Nov2009, Vol. 23 Issue 11, p2075 

    In probing the cell of origin in malignant B cells, an imprint of somatic hypermutation (SHM) in immunoglobulin (Ig) variable (V) region genes delineates antigen encounter, and identifying the precise pathway generating SHM in the normal B-cell counterpart becomes relevant. SHM remains the...

  • RITUXIMAB IN THE TREATMENT OF THE VARIANT OF HAIRY CELL LEUKAEMIA: A CASE REPORT. Hadzi-Pecova, L.; Stojanovik, A.; Petrusevska, G.; Panovska, I. // Contributions of Macedonian Academy of Sciences & Arts;2008, Vol. 29 Issue 2, p355 

    Hairy cell leukaemia (HCL) is an uncommon, low-grade B-cell lymphoproliferative disorder. HCL-variant describes an entity of HCL that is important from the point of view of requiring differential diagnosis from HCL, and for requiring careful consideration of the treatment approach. HCL-variant...

  • Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India. Gupta, Arvind Kumar; Singh Sachdeva, Man Updesh; Ahluwalia, Jasmina; Das, Reena; Naseem, Shano; Sharma, Prashant; Kumar, Narender; Malhotra, Pankaj; Varma, Neelam; Varma, Subhash // Indian Journal of Medical Research;Oct2015, Vol. 142 Issue 4, p426 

    Background & objectives: Hairy cell leukaemia (HCL) is a B cell neoplasm which constitutes around 2 per cent of all the lymphoid leukaemias. It has a characteristic morphology and immunophenotypic profile. It is important to distinguish HCL from other B cell lymphoproliferative disorders due to...

  • A rare combination of an endocrine tumour of the common bile duct and a follicular lymphoma of the ampulla of Vater: a case report and review of the literature. Athanasopoulos, Panagiotis G.; Arkadopoulos, Nikolaos; Stafyla, Vania; Tympa, Aliki; Kairi, Evi; Ryzman-Louloudis, Charlotte; Smyrniotis, Vassilios // World Journal of Surgical Oncology;2011, Vol. 9 Issue 1, p1 

    Carcinoid tumours of the common bile duct represent an extremely rare entity. Similarly, primary follicular lymphomas of the ampulla of Vater constitute an infrequent neoplasia. Herein, we report the first case of a synchronous development of a carcinoid tumour of the common bile duct and an...

  • A microRNA signature specific for hairy cell leukemia and associated with modulation of the MAPK-JNK pathways. Kitagawa, Y; Brahmachary, M; Tiacci, E; Dalla-Favera, R; Falini, B; Basso, K // Leukemia (08876924);Dec2012, Vol. 26 Issue 12, p2564 

    The authors discuss the significant progress in the understanding of the hairy cell leukemia (HCL) pathogenesis, a chronic B-cell lymphoproliferative disorder characterized by marked proliferation of tumor cells.They perform miRNA-expression profiling on peripheral blood-derived CD19 + B cells...

  • Hairy cell leukemia. Ronan Swords; Francis Giles // Medical Oncology;Jan2007, Vol. 24 Issue 1, p7 

    Abstract  Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder characterized by pancytopenia and variable infiltration of the reticuloendothelial system with “hairy” lymphocytes. HCL is more common in men than women and has a median age of diagnosis of 52...

  • Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. Henry Y Dong; James Weisberger; Zach Liu; Sorina Tugulea // American Journal of Clinical Pathology;Apr2009, Vol. 131 Issue 4, p586 

    CD103 is characteristically expressed in hairy cell leukemia (HCL), a B-lymphoproliferative disorder highly responsive to treatment with purine analogs. Other CD103+ diseases are rare and do not respond well to the same therapy, including HCL variant (HCLv) and splenic marginal zone B-cell...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics