Decrease of colonic dysplastic lesions induced by 1,2- dimetylhydrazine in butyric acid supplemented rats

Catuogno, M. S.; Montenegro, M. A.; Sanchez Negrette, M.; Ramirez, G. V.
May 2011
Revista Veterinaria;2011, Vol. 22 Issue 1, p13
Academic Journal
The butyric acid is considered as an anticancerigenou compound in several models of experimental carcinogenesis. It is one of the end products of the non- gaseous fermentation carried out by the microbial anaerobic flora of the mammalian large bowel and rumen. The milk and dairy products are the main ource of butyric acid among the animal products. The aim of this study was to determine the antitumorigenic effect of butyric acid on the development of dy plastic lesions, con idered as unequivocal histologic markers of colon cancer in its initial tate, in 1,2- dymethylhidrazine- treated rats. Six- week- old Wistar male rats with average body weight of 160 g were used. Butyric acid was administered diluted in drinking water at the do e of 4 mg/ml for 26 weeks. Dysplastic lesions in the large bowel were induced by a weekly subcutaneous injection of 1,2- dymethylhidrazine during 17 and 5 times to respective ub- groups. Less incidence of dyspla tic lesions was observed in butyric acid- supplemented groups, both in sub- group with 17 inoculations and in the sub- group with 5 inoculations, compared to control ub- groups (without supplementation). The dysplastic lesions a! o displayed variation in the mucin content depending on the severity of the dysplasia. We conclude that the u e of butyric acid a an antitumorigenic compound, would be the reason for the marked decrea eon the development of precarcinomatous lesions, considered as important precursors of colon carcinomas.


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