Manage peptic ulcer disease in the elderly with proton pump inhibitors and additional measures as needed

March 2011
Drugs & Therapy Perspectives;Mar2011, Vol. 27 Issue 3, p9
Academic Journal
The rates of peptic ulcer-related hospitalization and mortality are high among elderly patients. Gastric acid suppression with proton pump inhibitors is the mainstay of treatment and should be used in combination with antibacterial agents for the eradication of Helicobacter pylori infection.


Related Articles

  • Peptic Ulcer Disease in Older People. Lockrey, Gregory; Lim, Lucy // Journal of Pharmacy Practice & Research;Mar2011, Vol. 41 Issue 1, p58 

    Peptic ulcer disease is a common disorder that affects millions of people worldwide. When complications occur, peptic ulcer disease can have a major impact on quality of life and on the utilisation of the health system. Understanding the causative roles of Helicobacterpylori and non-steroidal...

  • Naproxen/Esomeprazole Fixed-Dose Combination: For the Treatment of Arthritic Symptoms and to Reduce the Risk of Gastric Ulcers. Dhillon, Sohita // Drugs & Aging;2011, Vol. 28 Issue 3, p237 

    Naproxen/esomeprazole is a fixed-dose combination of the NSAID naproxen and the proton pump inhibitor esomeprazole. In two well designed, 12-week studies, naproxen/esomeprazole fixed-dose combination was noninferior to celecoxib in treating the signs and symptoms of disease in patients with...

  • Gastroduodenal Complications of Chronic NSAID Therapy. Graham, David Y.; Smith, J. Lacey // American Journal of Gastroenterology (Springer Nature);Oct1988, Vol. 83 Issue 10, p1081 

    The fact that nonsteroidal anti-inflammatory drugs (NSAIDs) damage the gastroduodenal mucosa is no longer contested. Endoscopic studies in normal volunteers after NSAID administration have failed to predict which NSAIDs would be safest when administered chronically. NSAID use has been associated...

  • Acute Upper Gastrointestinal Bleeding in the Elderly. Ahmed, Asma; Stanley, Adrian J. // Drugs & Aging;2012, Vol. 29 Issue 12, p933 

    Acute upper gastrointestinal bleeding (UGIB) is a common, potentially life threatening medical emergency. It is associated with higher rates of hospitalization, morbidity and mortality in the elderly when compared with younger patients, most likely due to higher prevalence of multiple...

  • Treatment of Peptic Ulcer. Tytgat, Guido N. J. // Digestion;1998, Vol. 59 Issue 5, p446 

    The current therapy of choice for all Helicobacter pylori-associated ulcer disease is eradication therapy. Although adequate therapeutic regimens are currently available, often still ineffective therapies are tried. Cure of the infection essentially eliminates the ulcer diathesis. Cure of the...

  • COX-2 inhibitor no safer than naproxen and PPI.  // Journal of Family Practice;Mar2006, Vol. 55 Issue 3, p192 

    The article discusses on the study that determines which is safer between celecoxib and naproxen taken with a proton pump inhibitor in treating patients with previous peptic ulcer in Hong Kong, China. Celecoxib was given to patients who were at high risk for persistent occurrence of peptic ulcer...

  • Decreasing incidence of peptic ulcer complications after the introduction of the proton pump inhibitors, a study of the Swedish population from 1974-2002. Hermansson, Michael; Ekedahl, Anders; Ranstam, Jonas; Zilling, Thomas // BMC Gastroenterology;2009, Vol. 9, Special section p1 

    Background: Despite a decreasing incidence of peptic ulcer disease, most previous studies report a stabile incidence of ulcer complications. We wanted to investigate the incidence of peptic ulcer complications in Sweden before and after the introduction of the proton pump inhibitors (PPI) in...

  • Omeprazole: A Review of its Use in Helicobacter pylori Infection, Gastro-Oesophageal Reflux Disease and Peptic Ulcers Induced by Nonsteroidal Anti-Inflammatory Drugs. Langtry, H.D.; Wilde, M.I. // Drugs;Sep1998, Vol. 56 Issue 3, p447 

    Omeprazole is a well studied proton pump inhibitor that reduces gastric acid secretion. This review examines its use in Helicobacter pylori infection, gastro-oesophageal reflux disease (GORD) with or without oesophagitis and gastrointestinal damage caused by nonsteroidal anti-inflammatory drugs...

  • Peptic Ulcer Disease. Ramakrishnan, Kalyanakrishnan; Salinas, Robert C. // American Family Physician;10/1/2007, Vol. 76 Issue 7, p1005 

    Peptic ulcer disease usually occurs in the stomach and proximal duodenum. The predominant causes in the United States are infection with Helicobacter pylori and use of nonsteroidal anti-inflammatory drugs. Symptoms of peptic ulcer disease include epigastric discomfort (specifically, pain...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics