TITLE

C1q complement component and -antibodies reflect SLE activity and kidney involvement

AUTHOR(S)
Horák, P.; Heřmanová, Z.; Zadražil, J.; Ciferská, H.; Ordeltová, M.; Kusá, L.; Žurek, M.; Tichý, T.
PUB. DATE
August 2006
SOURCE
Clinical Rheumatology;Aug2006, Vol. 25 Issue 4, p532
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The role of the complement system in the pathogenesis of systemic diseases is very ambivalent. In systemic lupus erythematosus (SLE), many abnormalities in the activation of the complement system have been reported. The most important antibodies formed against the complement system in SLE are the ones associated with the C1q component. The aim of this study was to assess separately the anti-C1q antibodies and C1q component in the serum from 65 patients with SLE, then in individuals with ( n=33) and without ( n=32) lupus nephritis and with active ( n=36) and nonactive ( n=29) form of the disease (European Consensus Lupus Activity Measurement, ECLAM>3, ECLAM≤3). This study also aims to look for correlations with other clinical and laboratory parameters. The C1q antibodies were measured by the Enzyme-Linked Immunosorbent Assay (ELISA) test, while radial immunodiffusion according to Mancini was used to measure the C1q complement component. The mean serum levels were 90.89±13 IU/ml for anti-C1q antibodies and 145±52 mg/l for C1q. The significant difference in C1q antibodies levels was found between individuals with and without lupus nephritis (117.5±52 IU/ml vs. 28.2±12.2 IU/ml, p=0.0001) and between those with active and nonactive SLE (154.6±115 IU/ml vs. 50.6±73, p=0.001). C1q complement component was statistically lower in patients with lupus nephritis (144±30 mg/l vs. 175±50 mg/ml, p=0.002) and in active patients (138±40 mg/l vs. 202±20 mg/l, p=0.001). If the two parameters are measured together, they seem to have a mirror-like pattern of serum concentration, and they are potential markers of SLE activity and of the presence of lupus nephritis.
ACCESSION #
69959389

 

Related Articles

  • Membranous lupus nephritis. Austin, H. A.; Illei, G. G. // Lupus;2005, Vol. 14 Issue 1, p65 

    Membranous lupus nephritis (MLN) represents about 20% of clinically significant renal disease in lupus. Few studies have addressed directly the pathogenesis of MLN. Our assumptions about the underlying mechanisms are based on the combination of extrapolations from idiopathic membranous nephritis...

  • Two cases of systemic lupus erythematosus complicated by hydronephrosis and unique small structures observed in the glomerular basement membrane. Jinguji, Yoshimi; Nukui, Ikuo; Wakasugi, Masakiyo; Yamashita, Haruo // Clinical & Experimental Nephrology;Dec2008, Vol. 12 Issue 6, p467 

    We report two cases having a similar clinical profile of systemic lupus erythematosus (SLE) complicated by hydronephrosis that developed concurrently with a similar pathological recognition of numerous unique microspherical and microtubular structures in the glomerular basement membrane (GBM)....

  • A case of systemic lupus erythematosus showing invagination of the podocyte into the glomerular basement membrane: an electron microscopic observation of a repeated-renal biopsy. Sato, Masashi; Kogure, Teruko; Kanemitsu, Mineko // Clinical & Experimental Nephrology;Dec2008, Vol. 12 Issue 6, p455 

    A case of systemic lupus erythematosus (SLE) showing invagination of glomerular epithelial cells into the glomerular basement membrane (GBM) has been reported. The patient was a 30-year-old woman who was diagnosed with SLE at the age of 25 and had been medicated with corticosteroid. At the age...

  • Lupus nephritis flares. Sidiropoulos, P. I.; Kritikos, H. D.; Boumpas, D. T. // Lupus;2005, Vol. 14 Issue 1, p49 

    The clinical course of lupus nephritis varies remarkably among SLE patients, even between those with the same histological type. Current immunosuppressive agents induce remission in the majority of the patients with proliferative lupus nephritis, but a substantial proportion of them –...

  • Pathology of lupus nephritis. Lewis, E. J.; Schwartz, M. M. // Lupus;2005, Vol. 14 Issue 1, p31 

    The glomerular pathology of lupus nephritis is the result of diverse immune insults which are probably of independent pathogenetic origins. Although lupus nephritis is looked upon as a classic example of immune complex-induced microvascular injury resulting from circulating DNA double stranded...

  • Clinical presentation and monitoring of lupus nephritis. Balow, J. E. // Lupus;2005, Vol. 14 Issue 1, p25 

    The diversity of clinical presentations of lupus nephritis parallel the diversity of pathologic lesions seen in the kidneys of patients with SLE. Renal manifestations range from asymptomatic hematuria or proteinuria to overt nephritic and nephrotic syndromes, rapidly progressive...

  • Pathogenic autoantibodies in lupus nephritis. Waldman, M.; Madaio, M. P. // Lupus;2005, Vol. 14 Issue 1, p19 

    Lupus nephritis is a major complication of systemic lupus erythematosus (SLE) and is associated with a high rate of morbidity and mortality. While many different immunologic and nonimmunologic factors contribute to disease expression in lupus nephritis, a large body of evidence suggests that the...

  • Genetics of lupus nephritis. Lauwerys, B. R.; Wakeland, E. K. // Lupus;2005, Vol. 14 Issue 1, p2 

    Susceptibility to lupus nephritis is the end-result of complex interactions between polymorphic genetic factors involved in the regulation of immune responses. In humans, genome-wide screens and candidate-gene analyses led to the identification of several loci containing potential targets...

  • Renal transplantation in lupus nephritis. Ponticelli, C.; Moroni, G. // Lupus;2005, Vol. 14 Issue 1, p95 

    Most patients with systemic lupus erythematosus (SLE) are suitable candidates for renal transplantation. However, a number of them may present some disease-related problems. As cardiovascular disease is a leading cause of morbidity and mortality in SLE patients, a careful pretransplant...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics