Papillary thyroid carcinoma with nodular fasciitis-like stroma: A case report

Nandeesh, Bevinahalli N.; Ananthamurthy, Anuradha; Inchara, Yeliur K.; Correa, Marjorie M. A.; Garg, Isha
October 2011
ENT: Ear, Nose & Throat Journal;Oct2011, Vol. 90 Issue 10, pE8
Academic Journal
Papillary thyroid carcinoma (PTC) is the most frequently occurring malignant neoplasm of the thyroid gland and is known to have several morphologic variants. PTC with nodular fasciitis-like stroma (PTC-NFS) is one of the unusual variants of PTC, with only a few cases being reported in the literature. This neoplasm is characterized by extensive reactive stromal proliferation, which may occupy 60 to 80% of the tumor along with areas of a typical papillary carcinoma. We report a case of PTC-NFS and address the diagnostic difficulties posed by the condition's extensive reactive stromal proliferation. We also emphasize that when one encounters a fibroproliferative lesion of the thyroid, a diligent search should also be made for PTC to avoid diagnostic errors.


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