TITLE

Didanosine Resistance in HIV-infected Patients Switched from Zidovudine to Didanosine Monotherapy

AUTHOR(S)
Kozal, Michael J.; Kroodsma, Kenda; Winters, Mark A.; Shafer, Robert W.; Efron, Brad; Katzenstein, David A.; Merigan, Thomas C.
PUB. DATE
August 1994
SOURCE
Annals of Internal Medicine;8/15/94, Vol. 121 Issue 4, p263
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Determines the frequency and pattern of development of specific drug resistance mutations for HIV reverse transcriptase in patients switched from zidovudine to didanosine therapy. Serum HIV RNA preparation for virus burden; CD4 T-cell changes related to HIV reverse-transcriptase genotype; Relation of changes in serum virus burden in patients receiving didanosine monotherapy to the genotype at codon 74 of HIV reverse-transcriptase gene.
ACCESSION #
6977652

Tags: ANTIVIRAL agents;  REVERSE transcriptase

 

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