TITLE

Neoplastic Bone Marrow Niche: Hematopoietic and Mesenchymal Stem Cells

AUTHOR(S)
Najmaldin Saki; Abroun, Saeid; Hagh, Majid Farshdousti; Asgharei, Farahnaz
PUB. DATE
September 2011
SOURCE
Cell Journal (Yakhteh);Autumn2011, Vol. 13 Issue 3, p131
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The neoplastic niche comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. These niches are important for both the maintenance of cancer stem cells and the induction of neoplastic cells survival and proliferation. Each niche contains a population of tumor stem cells supported by a closely associated vascular bed comprising mesenchyme- derived cells and extracellular matrix. Targeting cancer stem cells and neoplastic niche may provide new therapies to eradicate tumors. Much progress has been very recently made in the understanding of the cellular and molecular interactions in the microenvironment of neoplastic niches. This review article provides an overview of the neoplastic niches in the bone marrow. In addition to highlighting recent advances in the field, we will also discuss components of the niche and their signaling pathways.
ACCESSION #
69719271

 

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