Role of Copper in Oral Submucous Fibrosis: A Cytological Correlation

Gupta, Nitin; Saxena, Susmita; Gupta, Siddharth; Gupta, Seema; Singh, Vishal; Yadav, Jyoti
December 2011
Indian Journal of Dental Sciences;Dec2011, Vol. 3 Issue 5, p29
Academic Journal
Oral submucous fibrosis is a chronic fibrotic disease of the oral cavity and oropharynx and is associated with the habit of chewing areca nut. Areca nut has a high copper content that plays a definitive role in the etiopathogenesis of Oral submucous fibrosis. The present study was contemplated to evaluate and compare the intensity of copper specific Rhodanine stain in buccal epithelial cells of 10 cases of normal oral mucosa, 20 cases of arecanut chewer patients without lesion and 10 histopathologically confirmed cases of oral submucous fibrosis using Rhodanine stain. Smears from non-chewers dipped in a copper sulphate solution were used as positive control for copper. A comparison was also done between these patients in relation to duration of the habit. The unpaired student's't' test was used to compare the mean scores of copper analyzed between the groups mentioned above. A 'p' value of less than 0.05 was considered to be statistically significant. The mean value of cells with copper granules showing positivity score in Normal oral mucosa, arecanut chewers and oral submucous fibrosis were 0±0, 31.1 3.8237 and 44.3 2.9833 respectively. The z test was applied to compare the values with regard to duration of arecanut chewing habit. The results showed a 5 % level of statistically significant difference between normal, arecanut chewer subjects, and OSMF subjects. Copper granules in large number of epithelial cells in cases of OSMF were more compared to that of the chewers without lesion, thus suggesting the role of copper in the pathogenesis of oral submucous fibrosis.


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