TITLE

Mesenchymal Dental Stem Cells for Tissue Regeneration

AUTHOR(S)
Honda, Masaki J.; Watanabe, Eri; Mikami, Yoshikazu; Saito, Yoko; Toriumi, Taku; Shirakawa, Tetsuo; Shimizu, Noriyoshi; Watanabe, Nobukazu; Isokawa, Keitaro
PUB. DATE
December 2011
SOURCE
Oral & Craniofacial Tissue Engineering;2011, Vol. 1 Issue 4, p279
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Two types of dentition are generated in a human's lifetime: the primary dentition, followed by the permanent dentition. Undoubtedly, teeth are essential for speech and mastication in both dentitions, but it is becoming apparent that dental pulp also plays a role in harboring mesenchymal stem cells (MSCs). To date, three kinds of MSCs derived from dental pulp have been established: permanent tooth, primary tooth, and immature apical papilla. The dental pulp from primary teeth is considered a particularly good source of MSCs; it can be obtained from extracted primary teeth, of which humans have 20. The past decade has seen many reports of dental pulp-derived MSCs, and the ield is becoming increasingly popular. The present article describes the characterization of dental pulp-derived MSCs from primary teeth. It also discusses future banking activity of primary teeth, because it is known that dental pulp-derived MSCs have similar potential to those derived from bone marrow. Methods with which to optimize the cryopreservation process should therefore be investigated, because banked dental pulp may provide a great resource in future regenerative medicine.
ACCESSION #
69651010

 

Related Articles

  • Mesenchymal Cell Community Effect in Whole Tooth Bioengineering. Yang, L.; Angelova Volponi, A.; Pang, Y.; Sharpe, P. T. // Journal of Dental Research;Feb2017, Vol. 96 Issue 2, p186 

    In vitro expanded cell populations can contribute to bioengineered tooth formation but only as cells that respond to tooth-inductive signals. Since the success of whole tooth bioengineering is predicated on the availability of large numbers of cells, in vitro cell expansion of tooth-inducing...

  • Isolation and culture of dental pulp stem cells from permanent and deciduous teeth. Naz, Shagufta; Khan, Farhan Raza; Zohra, Raheela Rahmat; Lakhundi, Sahreena Salim; Khan, Mehwish Sagheer; Mohammed, Nuruddin; Ahmad, Tashfeen // Pakistan Journal of Medical Sciences;Jul/Aug2019, Vol. 35 Issue 4, p997 

    Objective: To isolate dental pulp mesenchymal stem cells (MSCs) from non-infected human permanent and deciduous teeth. Methods: It was an in-vitro experimental study. Human teeth were collected from 13 apparently healthy subjects including nine adults and four children. After decoronation dental...

  • Regenerative endodontics. Simon, S.; Smith, A. J. // British Dental Journal;3/21/2014, Vol. 216 Issue 6, pE13 

    Background Significant advances in our understanding of the biological processes involved in tooth development and repair at the cellular and molecular levels have underpinned the newly emerging area of regenerative endodontics. Development of treatment protocols based on exploiting the natural...

  • Characterization of deciduous teeth stem cells isolated from crown dental pulp. Martačić, Jasmina Debeljak; Francuski, Jelena; Lužajić, Tijana; Vuković, Nemanja; Mojsilović, Slavko; Drndarević, Neda; Petakov, Marijana; Glibetić, Marija; Marković, Danica; Radovanović, Anita; Todorović, Vera; Filipović, Milica Kovačević // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;2014, Vol. 71 Issue 8, p735 

    Background/Aim. The last decade has been profoundly marked by persistent attempts to use ex vivo expanded and manipulated mesenchymal stem cells (MSCs), as a tool in different types of regenerative therapy. In the present study we described immunophenotype and the proliferative and...

  • Comparison of The Growth Curves of Mesenchymal Stem Cells Isolated from Third Molar and First Premolar Human Dental Pulp. Mahdiyar, P.; Tamadon, A. D.; Zare, Sh.; Robati, R.; Torabi, K.; Tamadon, A.; Mehrabani, D. // Cell Journal (Yakhteh);Summer 2013 Supplement 1, Vol. 15 Issue Sup 1, p54 

    Objective: Based on previous researches, dental pulp stem cells (DPSCs) were primarily derived from the pulp tissues of permanent third molar teeth. Their embryonic origin, from neural crests, explains their multipotency. These cells are easily accessible with limited morbidity after collection....

  • Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation. Xavier, Guilherme M.; Patist, Amanda L.; Healy, Chris; Pagrut, Ankita; Carreno, Gabriela; Sharpe, Paul T.; Pedro Martinez-Barbera, Juan; Thavaraj, Selvam; Cobourne, Martyn T.; Andoniadou, Cynthia L. // Scientific Reports;10/2/2015, p14479 

    In common with most mammals, humans form only two dentitions during their lifetime. Occasionally, supernumerary teeth develop in addition to the normal complement. Odontoma represent a small group of malformations containing calcified dental tissues of both epithelial and mesenchymal origin,...

  • Loss of permanent mandibular lateral incisor and canine tooth buds through extraoral sinus: report of a case. Kalaskar, R. R.; Damle, S. G.; Kalaskar, Ritesh R // Journal of the Indian Society of Pedodontics & Preventive Dentis;Mar2006, Vol. 24 Issue 1, p50 

    Extraoral sinus tract may occur as a result of an inflammatory process associated with the necrotic pulp. Several non odontogenic disorders may also produce an extraoral sinus tract, the differential diagnosis of these clinical findings is of prime importance in providing appropriate clinical...

  • Dental stem cells and their promising role in neural regeneration: an update. Martens, W.; Bronckaers, A.; Politis, C.; Jacobs, R.; Lambrichts, I. // Clinical Oral Investigations;Dec2013, Vol. 17 Issue 9, p1969 

    Introduction: Stem cell-based therapies are considered to be a promising treatment method for several clinical conditions such as Alzheimer's disease, Parkinson's disease, spinal cord injury, and many others. However, the ideal stem cell type for stem cell-based therapy remains to be elucidated....

  • Contribution of Mesenchymal Proliferation in Tooth Root Morphogenesis. Sohn, W.-J.; Choi, M.-A.; Yamamoto, H.; Lee, S.; Lee, Y.; Jung, J.-K.; Jin, M.-U.; An, C.-H.; Jung, H.-S.; Suh, J.-Y.; Shin, H.-I.; Kim, J.-Y. // Journal of Dental Research;Jan2014, Vol. 93 Issue 1, p78 

    In mouse tooth development, the roots of the first lower molar develop after crown formation to form 2 cylindrical roots by post-natal day 5. This study compared the morphogenesis and cellular events of the mesial-root-forming (MRF) and bifurcation-forming (BF) regions, located in the mesial and...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics