Middle Cerebral Artery Infarction in Central Nervous System Tuberculosis

Shahbaz, Naila; Hassan, Yasmeen; Kashif, Saima; Abdullah, Mohammed
July 2011
Pakistan Journal of Medical Sciences;Jul2011, Vol. 27 Issue 4, p802
Academic Journal
Objective: To show the occurrence of medium vessel vasculitis in patients with central nervous system tuberculosis, meningitis and/or tuberculomas, which we do not see infrequently, but which is rarely reported in the literature. Methodology: It was a prospective, observational study conducted at Department of Neurology, Dow University of Health Sciences, Karachi from January 2008 to June 2010. (Only five cases presented to Civil Hospital, Karachi directly; out of other five three patients were seen by the primary author at a charitable hospital which does not provide admitting facilities and therefore were brought to Civil Hospital and other two were seen at a private clinic which does offer admission facilities but patients could not financially afford to stay in those hospitals were also brought to Civil Hospital). Results: A total of 10 patients with central nervous system tuberculosis who also had stroke as a result of medium vessel vasculitis, middle cerebral artery infarction in all of our cases, were analyzed. There was equal number of male and female patients with an age range of 7-54 years. Two patients had stroke at presentation and two developed after 8 weeks of treatmentwhile remaining patients had stroke between 1-4 weeks. None of the patients had evidence of extrneural tuberculosis and only two patients had other risk factors for stroke which were convincingly ruled out as cause for stroke at that time. Three patients also had small vessel vasculitis in addition to larger stroke. Only one patient expired, one made complete recovery and 8 patients made partial recovery. Conclusion: Although small vessel vasculitis is a known complication of CNS tuberculosis, medium vessel vasculitis is not uncommon and contribute significantly to the mortality and morbidity of the infection.


Related Articles

  • Primary Angiitis of the Central Nervous System. Pourmahmoodian, Hossein; Omrani, Hossein Ali Ghelichnia; Harrirchian, Mohammad Hossein; Ghabaee, Mojdeh; Zamani, Babak; Ghaffarpour, Majid // Acta Medica Iranica;2012, Vol. 50 Issue 3, p216 

    Primary angiitis of the central nervous system (PACNS) is an idiopathic disorder (vasculitis) restricted to the central nervous system (CNS). It often presents with focal neurological deficits suggesting stroke or a combination of confusion and headache. We herein report three cases with various...

  • Recent presentations of neurological tuberculosis. Lindsay, I.; Scholtz, C. L. // Journal of the Royal Society of Medicine;Mar1978, Vol. 71 Issue 3, p223 

    The article presents several case report on patient with symptoms of tuberculous meningitis that includes a 20-year old Indian male who died three weeks after admission with various symptoms of pulmonary tuberculosis and infarctions in the brain, a 56-year old Jamaican male who died three days...

  • Updated Definition of Stroke Incorporates Decades of Research. Greb, Erik // Neurology Reviews;Apr2014, Vol. 22 Issue 4, p5 

    Information about the views of Scott Kasner, Professor of Neurology, on the new definition of stroke expressed at the 2014 International Stroke Conference held in San Diego, California as of April 2014, is presented. It mentions that the new definition for central nervous system (CNS) infarction...

  • Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. Wasay, Mohammad; Farooq, Salman; Khowaja, Zubair Ali; Bawa, Zeeshan Ali; Ali, Shehzad Mansoor; Awan, Safia; Asim Beg, M.; Mehndiratta, Man Mohan // Journal of Neurology, Neurosurgery & Psychiatry;Nov2014, Vol. 85 Issue 11, p1260 

    Background: Tuberculoma and cerebral infarctions are serious complications of central nervous system (CNS) tuberculosis. However, there are no studies comparing prognostic value of tuberculoma and infarcts alone and in patients diagnosed with CNS tuberculosis. Objective: The objective of this...

  • Central nervous system vasculitis. Carolei, A.; Sacco, S. // Neurological Sciences;May2003 Supplement 1, Vol. 24, ps8 

    Vasculitis is an inflammation of the vessel wall. It may be either primary or secondary. Primary vasculitis includes systemic vasculitis (large, medium, and small-vessel vasculitis) and localized vasculitis (isolated angiitis of the central nervous system and non-systemic vasculitic neuropathy)....

  • Biopsy-proven fulminant primary angiitis of the central nervous system with normal arteriography: a challenging diagnosis of recurrent ischemic strokes. Safouris, Apostolos; Stricker, Julien; Michotte, Alex; Voumvourakis, Konstantinos; Gazagnes, Marie-Dominique; Tsivgoulis, Georgios // Neurological Sciences;Jan2014, Vol. 35 Issue 1, p135 

    No abstract available.

  • Eye complications in cerebral vasculitis. Galleta, Steven L. // Ophthalmology Times;10/01/97, Vol. 22 Issue 19, p6 

    Focuses on the diagnostic approaches for central nervous system (CNS) vasculitis. Applications of the term vasculitis; Two categories of cerebral vasculitis based on their characteristics; Suggested medical examinations and confirmatory evaluations for the disease; Determinants of an effective...

  • Multiple Symptoms of a Neurologic Puzzle. Rempe, David A. // Cortlandt Forum;08/25/2000, Vol. 13 Issue 8, p48 

    Presents a clinical case of a stroke due to primary angiitis of the central nervous system (PACNS), a rare vasculitis involving only the cerebral vessels. Common symptoms of PACNS; Association of isolated CNS vasculitis with a variety of causes; Differentiation between PACNS and system...

  • Primary angiitis of the central nervous system in children - case series. Krakovská, V.; Stibitzová, R.; Pískovský, T.; Vrábelová, Z.; Macků, M.; Němcová, D.; Doležalová, P. // Pediatric Rheumatology;2011 Supplement, Vol. 9 Issue Suppl 1, p1 

    An abstract of the conference paper "Primary angiitis of the central nervous system in children - case series," by V. Krakovská and colleagues is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics