Frequency of depression in chronic Hepatitis C naïve patients

Memon, Sajjad Ali; Zuberi, Bader Faiyaz; Ashfaq, Makhdoom Naveed; Kiran, Zareen; Qadeer, Rashid; Memon, Abdul Rauf; Afsar, Salahuddin
July 2011
Pakistan Journal of Medical Sciences;Jul2011, Vol. 27 Issue 4, p780
Academic Journal
Objectives: To determine frequency of depression in chronic hepatitis C naïve patients before interferon therapy using CES-D questionnaire. Methodology: Patients testing positive antibodies to HCV by EIA of more than 6 months duration and who have not taken interferon therapy previously were included after taking informed consent. Patients who had co-infections such as hepatitis B and D virus or human immunodeficiency virus, or patients with other coexisting chronic liver disease like primary biliary cirrhosis, chronic autoimmune hepatitis and Wilson disease were excluded from study. Urdu version of CES-D a self-reporting questionnaire in public domain was administered. A score of >10 was taken consistent with depression. Results: Ninety-six patients were included and 59.4% were depressed. These included 57.9% males and 42.1% females. Highest frequency was seen in under-graduates and positive correlation was seen with duration of hepatitis C infection. Conclusions: This study showed that 59.4% of patients with hepatitis C have depression before initiation of therapy and this should be evaluated and treated if necessary before starting interferon therapy.


Related Articles

  • Serum Autoantibody Against Interleukin -- 1α is Unrelated to the Etiology or Activity of Liver Disease but Can be Raised by Interferon Treatment. Itoh, Yoshito; Okanoue, Takeshi; Sakamoto, Shinichi; Nishioji, Kenichi; Kashima, Kei; Ohmoto, Yasukazu // American Journal of Gastroenterology;May1995, Vol. 90 Issue 5, p777 

    Objective: To clarify the clinical significance of serum levels of interleukin-1α autoantibody in liver disease and their change during interferon therapy for chronic hepatitis. Methods: By radioimmunoassay, we studied the incidence of serum interleukin-1α autoantibody in 838 healthy...

  • Cognitive Function Does Not Worsen During Long-Term Low-Dose Peginterferon Therapy in Patients With Chronic Hepatitis C. Fontana, Robert J.; Bieliauskas, Linas A.; Back-Madruga, Carla; Lindsay, Karen L.; Litman, Heather J.; Lok, Anna S. F.; Kronfol, Ziad // American Journal of Gastroenterology;Jul2010, Vol. 105 Issue 7, p1551 

    OBJECTIVES:Neuropsychiatric toxicity is a common dose-limiting side effect of interferon therapy. The primary aim of this study was to determine whether patients receiving long-term low-dose peginterferon therapy had a higher incidence of cognitive side effects compared with untreated patients...

  • Nonresponder Patients with Hepatitis C Virus Genotype 2/3 Infection: A Question of Low Systemic Interferon Concentrations? Alsiö, Åsa; Christensen, Peer Brehm; Färkkilä, Martti; Langeland, Nina; Buhl, Mads Rauning; Pedersen, Court; Mørch, Kristine; Haagmans, Bart L.; Westin, Johan; Hellstrand, Kristoffer; Norkrans, Gunnar; Lagging, Martin // Clinical Infectious Diseases;2/15/2010, Vol. 50 Issue 4, pe22 

    Twelve of 303 per-protocol patients were nonresponders in a 12-week versus 24-week treatment study of hepatitis C virus (HCV) genotype 2/3 infection. The nonresponders had significantly lower interferon concentrations, as well as significantly greater mean age, body mass index, and viral load....

  • Interferon's Effects on Depression. Breindl, Anette // BioWorld Today;6/11/2012, Vol. 23 Issue 112, Special section p2 

    The article reports on a study which investigated the role of interferon-gamma treatment in depression among hepatitis C patients.

  • Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis. Baranyi, Andreas; Meinitzer, Andreas; Breitenecker, Robert J.; Amouzadeh-Ghadikolai, Omid; Stauber, Rudolf; Rothenhäusler, Hans-Bernd // PLoS ONE;9/14/2015, Vol. 10 Issue 9, p1 

    Background: The aim of this exploratory study is to gain for the first time a more comprehensive picture of the impact of changes of quinolinic acid concentrations on depressive symptomatology during and after IFN-α therapy. Methods: The quinolinic acid concentrations of 35 HCV patients are...

  • Depressive symptoms and cognitive dysfunction in patients with hepatitis C treated with interferon-α and ribavirine. Dróżdż, Wiktor; Borkowska, Alina; Halota, Waldemar; Rybakowski, Janusz K. // Archives of Psychiatry & Psychotherapy;Mar2008, Vol. 10 Issue 1, p85 

    Aim. The purpose of the study was an assessment of the prevalence of depressive symptoms and characteristic of cognitive functions in patients with hepatitis C before and after three month treatment with interferon-a plus ribavirine. Subject and methods. One hundred hepatitis C patients without...

  • Transfusion of Blood Components.  // Clinical Pediatrics;Jun1990, Vol. 29 Issue 6, p356 

    This article presents information on a report issued by the periodical "National Institutes of Health" related to the transfusion of blood components. The transfusion of blood components reminds health professionals that because of advances in the use of blood components, whole blood...

  • Serotonin Metabolism Parameters in Patients with Chronic Hepatitis and Liver Cirrhosis. A. Alekseeva; E. Beloborodova; M. Rachkovskiy; E. Naumova; E. Lambrov; L. Philippova // Bulletin of Experimental Biology & Medicine;Nov2008, Vol. 146 Issue 5, p577 

    We studied disorders in serotonin metabolism in patients with chronic hepatitis and cirrhosis of the liver with and without inflammatory process (cytolysis syndrome) and their impact for the formation of depressive disorders. Blood serotonin content decreased in patients with cirrhosis of the...

  • Peginterferon-α-2b.  // Reactions Weekly;8/21/2010, Issue 1315, p39 

    The article describes the case of a 72-year-old woman who developed autoimmune hepatitis after undergoing peginterferon-α-2b treatment for chronic hepatitis C.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics