TITLE

Discontinuation of thioridazine in patients with learning disabilities: balancing cardiovascular toxicity with adverse consequences of changing drugs

AUTHOR(S)
Davies, Simon J C; Cooke, Leila B; Moore, Alan G; Potokar, John
PUB. DATE
June 2002
SOURCE
BMJ: British Medical Journal (International Edition);6/22/2002, Vol. 324 Issue 7352, p1519
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Presents examples of the consequences of discontinuing established drugs in line with the advice of the Committee on Safety of Medicines. Topic of restrictive licensed indications for thioridazine antipsychotic drug, which was associated with prolonged QTc intervals, a marker for ventricular arrhythmias; Risk of changing drugs in patients with learning disabilities and psychiatric illness; Issue of informed consent; Suggestion that directives should allow clinicians greater flexibility in prescribing.
ACCESSION #
6893867

 

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