TITLE

Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

AUTHOR(S)
Yong-Mei Xie; Yu-Qin Yao; Hong-Bao Sun; Ting-Ting Yan; Jie Liu; Tai-Ran Kang
PUB. DATE
October 2011
SOURCE
Molecules;Oct2011, Vol. 16 Issue 10, p8745
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
ACCESSION #
68633667

 

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