Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

Souto, Augusto Lopes; Tavares, Josean Fechine; da Silva, Marcelo Sobral; Melo Diniz, Margareth de Fátima Formiga; de Athayde-Filho, Petrônio Filgueiras; Filho, José Maria Barbosa
October 2011
Molecules;Oct2011, Vol. 16 Issue 10, p8515
Academic Journal
Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited.


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