Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide

Leinisch, Fabian; JinJie Jiang; Deterding, Leesa J.; Mason, Ronald P.
October 2011
Molecules;Oct2011, Vol. 16 Issue 10, p8428
Academic Journal
5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.


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