Infection with Vaccinia Virus Alters Regulation of Cell Cycle Progression
- Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals. Barcia-Sanjurjo, Iria; Vázquez-Cedeira, Marta; Barcia, Ramiro; Lazo, Pedro // Journal of Biological Inorganic Chemistry;Apr2013, Vol. 18 Issue 4, p473
The human vaccinia-related kinase (VRK) proteins VRK1 and VRK2 regulate different processes, such as the cell cycle, DNA damage response, and signaling by mitogen-activated protein kinases in response to growth factors or cellular stress. Alterations in expression levels of these Ser-Thr kinases...
- Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells. Kim, Seong-Hoon; Ryu, Hye Guk; Lee, Juhyun; Shin, Joon; Harikishore, Amaravadhi; Jung, Hoe-Youn; Kim, Ye Seul; Lyu, Ha-Na; Oh, Eunji; Baek, Nam-In; Choi, Kwan-Yong; Yoon, Ho Sup; Kim, Kyong-Tai // Scientific Reports;10/2/2015, p14570
Many mitotic kinases have been targeted for the development of anti-cancer drugs, and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good targets and finding specific drugs to target are especially needed, largely due to the...
- The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53. Valbuena, Alberto; Blanco, Sandra; Vega, Francisco M.; Lazo, Pedro A. // PLoS ONE;2008, Vol. 3 Issue 7, p1
Background: The vaccinia-related kinase 1 (VRK1) protein, an activator of p53, can be proteolytically downregulated by an indirect mechanism, which requires p53-dependent transcription. Principal Findings: In this work we have biochemically characterized the contribution of several p53...
- The significance of the nuclear and cytoplasmic localization of metallothionein in human liver and tumor cells Cherian, M. George // Environmental Health Perspectives Supplements;1994 Supplement 3, Vol. 102, p131
No abstract available.
- A bioinformatics approach for the interrogation of molecular events in single cells: transforming fluorescent time-lapse microscopy images into numbers. Khan, Imtiaz; Fisher, Janet; Marquez, Nuria; Smith, Paul; Errington, Rachel // BMC Systems Biology;2007 Supplement 1, Vol. 1, pP31
An abstract of the article "A bioinformatics approach for the interrogation of molecular events in single cells: transforming fluorescent time-lapse microscopy images into numbers," by Imtiaz Khan, Janet Fisher, Nuria Marquez, Paul Smith, and Rachel Errington is presented.
- Induction of a caffeine-sensitive S-phase cell cycle checkpoint by psoralen plus ultraviolet A radiation. Joerges, Christoph; Kuntze, Inge; Herzinge, Thomas // Oncogene;2/3/2005, Vol. 24 Issue 6, p1128
Presents a correction to the article "Induction of a Caffeine-Sensitive S-Phase Cell Cycle Checkpoint by Psoralen Plus Ultraviolet A radiation," previously published in the periodical "Oncogene," vol. 24.
- Human Infection Due to Recombinant Vaccinia—Rabies Glycoprotein Virus. // New England Journal of Medicine;12/13/2001, Vol. 345 Issue 24, p1784
A correction to the article "Human Infection Due to Recombinant Vaccinia--Rabies Glycoprotein Virus," published in the August 23, 2001 issue of the "New England Journal of Medicine," is presented.
- Actin-based motility of vaccinia virus. Cudmore, Sally; Cossart, Pascale // Nature;12/7/1995, Vol. 378 Issue 6557, p636
Reports on the capability of the intracellular enveloped form of vaccinia virus to induce the formation of actin tails that are similar to those seen some infections. Role of cytoskeleton during viral infection; Speed of propelling of single viral particles on the tip of actin tails;...
- Crafty virus turns down the heat. Day, Michael // New Scientist;10/12/96, Vol. 152 Issue 2051, p15
Reports that researchers at the University of Oxford has discovered that vaccinia virus, used to vaccinate people against smallpox, releases a protein that prevents fever. Experiment on mice; Viral production of soluble receptor to the cytokine interleukin-1beta; Danger posed by high...