Genetic Live Vaccines Mimic the Antigenicity But Not Pathogenicity of Live Viruses
- Experimental vaccine protects monkeys against Ebola virus. Gottlieb, Scott // Bulletin of the World Health Organization;2001, Vol. 79 Issue 1, p79
Focuses on the experimental DNA vaccine developed by scientists for protecting the primates from ebola virus disease in the United States. Characteristics of the DNA vaccines; Details on the immunization program; Significance of prime-boost vaccination approach.
- Myth, menace or medical blessing? Leitner, Wolfgang W. // EMBO Reports;Mar2001, Vol. 2 Issue 3, p168
This article focuses on the clinical potential and the problems of genetic vaccines. Genetic vaccine is painless, bloodless, clean and completely safe. Oddly, the idea of a gene transfer raises irrational fear in many people who do not realize that we are under constant attack by viruses,...
- Prime-boost vaccines encoding an intracellular idiotype/GM-CSF fusion protein induce protective cell-mediated immunity in murine pre-B cell leukemia. Pasquini, S.; Peralta, S.; Missiaglia, E.; Cara, L.; Lemoine, N.R. // Gene Therapy;4/15/2002, Vol. 9 Issue 8, p503
Reports that prime-boost vaccines encoding an intracellular idiotype/GM-CSF fusion protein induce protective cell-mediated immunity in murine pre-B cell leukemia. DNA vaccine; Recombinant vaccinia virus; Cancer immunotherapy.
- Live virus vaccines: Something old, something new, something borrowed... Dubensky, Thomas W.; Polo, John M.; Liu, Margaret A. // Nature Medicine;Dec98, Vol. 4 Issue 12, p1357
A vaccine based on synthesized infectious viral RNA elicits protection against lethal virus challenge in an animal model (pages 1438?1440).
- Successful DNA immunization against measles: Neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles. Polack, Fernando P.; Lee, Sok H.; Permar, Sallie; Manyara, Elizabeth; Nousari, Hossein G.; Jeng, Yaikah; Mustafa, Farah; Valsamakis, Alexandra; Adams, Robert J.; Robinson, Harriet L.; Griffin, Diane E. // Nature Medicine;Jul2000, Vol. 6 Issue 7, p776
Measles remains a principal cause of worldwide mortality, in part because young infants cannot be immunized effectively. Development of new vaccines has been hindered by previous experience with a formalin-inactivated vaccine that predisposed to a severe form of disease (atypical measles). Here...
- 8 Br-cAMP enhances both humoral and cell-mediated immune responses induced by an HIV-1 DNA vaccine. Arai, H; Xin, K-Q; Hamajima, K; Lu, Y; Watabe, S; Takahashi, T; Toda, S; Okuda, K; Kudoh, I; Suzuki, M // Gene Therapy;Apr2000, Vol. 7 Issue 8, p694
From a series of preclinical studies and animal experiments, we have been able to demonstrate that DNA vaccines are a promising tool in strategies for protecting hosts from a variety of infectious diseases. Since the promoter activity of the human cytomegalovirus immediate-early promoter/...
- Polyclonal antibody cocktails generated using DNA vaccine technology protect in murine models of orthopoxvirus disease. // Virology Journal;2011, Vol. 8 Issue 1, p441
The article offers information on the study conducted by the authors related to the polyclonal antibody cocktails generated using DNA vaccine technology protect in murine models of orthopoxvirus disease. It states that the monkeypox virus (MPXV) is an emerging virus that causes endemic disease...
- The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes. Leifert, J. A.; Holler, P. D.; Harkins, S.; Kranz, D. M.; Whitton, J. L. // Gene Therapy;Dec2003, Vol. 10 Issue 25, p2067
The potential of genetic immunization has been acknowledged for almost a decade, but disappointing immunogenicity in humans has delayed its introduction into the clinical arena. To try to increase the potency of genetic immunization, we and others have evaluated â€˜translocatoryâ€™...
- Exploring Genetic Resistance to PRRS. Johnson, Rodger // National Hog Farmer;11/15/2003, Vol. 48 Issue 11, p10
Focuses on the immediate attention of the U.S. veterinary scientist and swine producers concerning porcine reproductive and respiratory syndrome (PRRS) virus. Genetic investigations conducted by the University of Nebraska concerning disease resistance genes as an alternative; Problems arising...