Exploring implementation and sustainability of models of care: can theory help?
- Standardizing CTA's: International Efforts. Goldfarb, Norman M. // Applied Clinical Trials;Feb2005, Vol. 14 Issue 2, p48
This article reports that most pharmaceutical companies place a high priority on reducing their costs to offset pressure on profit margins. Based on drug sale statistics, pharmaceutical companies lose substantial revenue each day a new drug is delayed from reaching the market. Pharmaceutical...
- When Does Innovative Care Become Clinical Research? Mackintosh, Douglas R.; Molloy, Vernette J. // Applied Clinical Trials;Feb2005, Vol. 14 Issue 2, p59
This article examines the overlapping of clinical research by medical care. There are compounds administered to patients, as well as procedures performed on patients that are unapproved, untested, and could in no way be considered the generally accepted standard of care. These therapies are...
- A Systematic Review of Studies That Aim to Determine Which Outcomes to Measure in Clinical Trials in Children. Sinha, Ian; Jones, Leanne; Smyth, Rosalind L; Williamson, Paula R // PLoS Medicine;Apr2008, Vol. 5 Issue 4, pe96
Ian Sinha and colleagues show, in a systematic review of published studies, that there are very few studies that address the appropriate choice of outcomes for clinical research with children.
- A Randomised, Blinded, Placebo-Controlled Trial in Dementia Patients Continuing or Stopping Neuroleptics (The DART-AD Trial). Ballard, Clive; Lana, Marisa Margallo; Theodoulou, Megan; Douglas, Simon; McShane, Rupert; Jacoby, Robin; Kossakowski, Katja; Yu, Ly-Mee; Juszczak, Edmund // PLoS Medicine;Apr2008, Vol. 5 Issue 4, pe76
In a randomized trial of patients with dementia, Clive Ballard and colleagues show that withdrawal of neuroleptics had no overall detrimental effect, and by some measures improved, functional and cognitive status.
- Is it better to consent to an RCT or to care? Dreyfuss, Didier // Intensive Care Medicine;Mar2005, Vol. 31 Issue 3, p345
The article cites that twenty-five years ago the Belmont report established a formal distinction between care and research in order to protect patients. The legitimate fear that research might be conducted under the pretence of medical care regardless of whether this increased the risk to...
- Infant Orthopedics and Facial Appearance: A Randomized Clinical Trial (Dutchcleft). Prahl, Charlotte; Prahi-Andersen, Birte; Van 't Hof, Martin A.; Kuijpers-Jagtman, Anne M. // Cleft Palate-Craniofacial Journal;Nov2006, Vol. 43 Issue 6, p659
Objective: To study the effect of infant orthopedics on facial appearance. Design: Prospective two-arm randomized controlled trial in parallel with three participating academic cleft palate centers. Treatment allocation was concealed and performed by means of a computerized balanced allocation...
- Clinical trial design in systemic lupus erythematosus: lessons learned and future directions. Strand, V. // Lupus;2004, Vol. 13 Issue 5, p406
Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between...
- Use of qualitative methods alongside randomised controlled trials of complex healthcare interventions: methodological study. Lewin, Simon; Glenton, Claire; Oxman, Andrew D. // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;9/26/2009, Vol. 339 Issue 7723, p732
Objective To examine the use of qualitative approaches alongside randomised trials of complex healthcare interventions. Design Review of randomised controlled trials of interventions to change professional practice or the organisation of care. Data sources Systematic sample of 100 trials...
- Designing Clinical Research Studies: Part III. Colling, Joyce // Urologic Nursing;Feb2004, Vol. 24 Issue 1, p58
Explains measurement issues in conducting clinical studies in medicine and nursing. Aspects of design associated with operationalizing concepts; Types of measurements to consider; Distinctions of measurement categories; Ways of analyzing data.