Exploring implementation and sustainability of models of care: can theory help?
- Standardizing CTA's: International Efforts. Goldfarb, Norman M. // Applied Clinical Trials;Feb2005, Vol. 14 Issue 2, p48
This article reports that most pharmaceutical companies place a high priority on reducing their costs to offset pressure on profit margins. Based on drug sale statistics, pharmaceutical companies lose substantial revenue each day a new drug is delayed from reaching the market. Pharmaceutical...
- When Does Innovative Care Become Clinical Research? Mackintosh, Douglas R.; Molloy, Vernette J. // Applied Clinical Trials;Feb2005, Vol. 14 Issue 2, p59
This article examines the overlapping of clinical research by medical care. There are compounds administered to patients, as well as procedures performed on patients that are unapproved, untested, and could in no way be considered the generally accepted standard of care. These therapies are...
- A Systematic Review of Studies That Aim to Determine Which Outcomes to Measure in Clinical Trials in Children. Sinha, Ian; Jones, Leanne; Smyth, Rosalind L; Williamson, Paula R // PLoS Medicine;Apr2008, Vol. 5 Issue 4, pe96
Ian Sinha and colleagues show, in a systematic review of published studies, that there are very few studies that address the appropriate choice of outcomes for clinical research with children.
- Is it better to consent to an RCT or to care? Dreyfuss, Didier // Intensive Care Medicine;Mar2005, Vol. 31 Issue 3, p345
The article cites that twenty-five years ago the Belmont report established a formal distinction between care and research in order to protect patients. The legitimate fear that research might be conducted under the pretence of medical care regardless of whether this increased the risk to...
- Infant Orthopedics and Facial Appearance: A Randomized Clinical Trial (Dutchcleft). Prahl, Charlotte; Prahi-Andersen, Birte; Van 't Hof, Martin A.; Kuijpers-Jagtman, Anne M. // Cleft Palate-Craniofacial Journal;Nov2006, Vol. 43 Issue 6, p659
Objective: To study the effect of infant orthopedics on facial appearance. Design: Prospective two-arm randomized controlled trial in parallel with three participating academic cleft palate centers. Treatment allocation was concealed and performed by means of a computerized balanced allocation...
- Clinical trial design in systemic lupus erythematosus: lessons learned and future directions. Strand, V. // Lupus;2004, Vol. 13 Issue 5, p406
Designing successful randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) poses many challenges. It remains difficult to correlate alterations in biologic markers with clinical outcome, especially when signs and symptoms are intermittent and broadly variable between...
- Designing Clinical Research Studies: Part III. Colling, Joyce // Urologic Nursing;Feb2004, Vol. 24 Issue 1, p58
Explains measurement issues in conducting clinical studies in medicine and nursing. Aspects of design associated with operationalizing concepts; Types of measurements to consider; Distinctions of measurement categories; Ways of analyzing data.
- How to make sense of clinical research. Wooten, James M.; Ross, Vicki M. // RN;Jan2005, Vol. 68 Issue 1, p22
Provides tips on how to evaluate research studies. Implication of research evaluation on patient care; Importance of statistical terms on research evaluation; Features of randomized controlled trials; Individual components of a research article.
- Integrating data to facilitate clinical research: a case study. Ackerman, Ilana N.; Osborne, Richard H. // Informatics in Primary Care;Dec2005, Vol. 13 Issue 4, p263
The integration of routine clinical administrative activities into ongoing rigorous clinical research poses challenges for both clinicians and researchers. This case study describes the development of a responsive database system used to facilitate comprehensive longitudinal research into the...