TITLE

Changing trends of chronic myeloid leukemia in greater Mumbai, India over a period of 30 years

AUTHOR(S)

Dikshit, Rajesh P.; Nagrani, Rajini; Yeole, Balkrishna; Koyande, Shravani; Banawali, Shripad

PUB. DATE

April 2011

SOURCE

Indian Journal of Medical & Paediatric Oncology;Apr-Jun2011, Vol. 32 Issue 2, p96

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Background: Little is known about burden of chronic myeloid leukemia (CML) in India. There is a recent interest to observe incidence and mortality because of advent of new diagnostic and treatment policies for CML. Materials and Methods: We extracted data from the oldest population-based cancer registry of Mumbai for 30 years period from 1976-2005 to observe incidence and mortality rates of CML. We classified the data into four age groups 0-14, 15-29, 30-54 and 55-74 to observe incidence rates in the respective age groups. Results: The age specific rates were highest for the age group of 55-74 years. No significant change in trends of CML was observed for 30 years period. However, there was a significant reduction in incidence rate for recent 15-years period (Estimated average annual percentage change=-3.9). No significant reduction in mortality rate was observed till 2005. Conclusion: The study demonstrates that age-specific rates for CML are highest in age group of 55-74 years, although they are lower compared to western populations. Significant reduction in incidence of CML in recent periods might be because of reduced misclassification of leukemias. The data of CML has to be observed for another decade to witness reduction in mortality because of changes in treatment management.

ACCESSION #

67721146

Tags: MYELOID leukemia;  DISEASE incidence;  MORTALITY

 

Related Articles

• Second malignancies among Waldenstrom macroglobulinemia patients: small samples and sparse data. Ojha, R. P.; Thertulien, R. // Annals of Oncology;Feb2012, Vol. 23 Issue 2, p542 

  No abstract available.

• Risk of second cancers in Waldenstr�m macroglobulinemia. Varettoni, M.; Tedeschi, A.; Arcaini, L.; Pascutto, C.; Vismara, E.; Orlandi, E.; Ricci, F.; Corso, A.; Greco, A.; Mangiacavalli, S.; Lazzarino, M.; Morra, E. // Annals of Oncology;Feb2012, Vol. 23 Issue 2, p411 

  Background: An increased incidence of second cancers has been reported in lymphoproliferative disorders. Patients and methods: We assessed the frequency, characteristics and predictive factors of second cancers in 230 patients with Waldenstr�m macroglobulinemia (WM) and compared the incidence...

• LEUCEMIE LIMFATICA CRONICA ASOCIATA CU LEUCEMIE ACUTA MIELOIDA PREZENTARE DE CAZ. Cocisiu, Gabriela Ariadna; Grandore, Cristina; Joitoiu, Alina // Acta Medica Transilvanica;sep2011, Vol. 16 Issue 3, p151 

  An increased incidence of different malignancies associated to chronic lymphocytic leukemia (CLL) has been reported and it is considered a complication of this disease. The association of CLL and acute leukemia is a rare event described in <1% of CLL, the acute leukemia has been of both the...

• Chronic myelogenous leukemia: ESMO Clinical Recommendations for diagnosis, treatment and follow-up. Baccarani, M.; Dreyling, M. // Annals of Oncology;May2009 Supplement 4, Vol. 20, piv105 

  The article presents clinical recommendations for diagnosis, treatment and follow-up of chronic myelogenous leukemia from the European Society for Medical Oncology (ESMO). The incidence of the disease is reported between 1 and 2 cases/100,000/year. The basis for diagnosis is blood counts and...

• Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With Imatinib. Gambacorti-Passerini, Carlo; Antolini, Laura; Mahon, Fran�ois-Xavier; Guilhot, Francois; Deininger, Michael; Fava, Carmen; Nagler, Arnon; Della Casa, Chiara Maria; Morra, Enrica; Abruzzese, Elisabetta; D'Emilio, Anna; Stagno, Fabio; le Coutre, Philipp; Hurtado-Monroy, Rafael; Santini, Valeria; Martino, Bruno; Pane, Fabrizio; Piccin, Andrea; Giraldo, Pilar; Assouline, Sarit // JNCI: Journal of the National Cancer Institute;Apr2011, Vol. 103 Issue 7, p553 

  Background Imatinib slows development of chronic myeloid leukemia (CML). However, available information on morbidity and mortality is largely based on sponsored trials, whereas independent long-term field studies are lacking. Patients and Methods Consecutive CML patients who started imatinib...

• Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors. Chen, D-F; Prasad, V K; Broadwater, G; Reinsmoen, N L; DeOliveira, A; Clark, A; Sullivan, K M; Chute, J P; Horwitz, M E; Gasparetto, C; Long, G D; Yang, Y; Chao, N J; Rizzieri, D A // Bone Marrow Transplantation;Jun2012, Vol. 47 Issue 6, p817 

  The impact of activating KIR (aKIR) and inhibitory KIR (iKIR) on OS, relapse-related mortality (RRM) and acute GVHD (aGVHD) was prospectively studied in 84 adults with high-risk hematologic malignancies receiving reduced intensity conditioning (RIC) T-cell depleted hematopoietic SCT (HSCT) from...

• Mortality patterns among female nurses: A 27-state study, 1984 through 1990. Peipins, Lucy A.; Burnett, Carol; Alterman, Toni; Lalich, Nina // American Journal of Public Health;Sep97, Vol. 87 Issue 9, p1539 

  Objectives. This study examined the mortality experience of 50 000 nurses using the National Occupational Mortality Surveillance database of death certificates. Methods. Proportionate mortality ratios adjusted by race (White, Black, or other) and 5-year age groups were calculated for selected...

• Frecuencia de leucemias agudas. González-Salas, Wendy Marlene; Olarte-Carrillo, Irma; Gutiérrez-Romero, Mario; Montaño-Figueroa, Efreen Horacio; Martínez-Murillo, Carlos; Ramos-Peñafiel, Christian Omar // Revista Medica del IMSS;2012, Vol. 50 Issue 2, p167 

  Objective: to compare the frequency of acute leukemia in two periods of study in a reference Hospital at Mexico City. Methods: it was an observational study. There were registered 250 cases with the morphology diagnostic criterion of acute leukemia. Results: 63 cases versus 92 of acute lymphoid...

• Epigenetic therapy is associated with similar survival compared with intensive chemotherapy in older patients with newly diagnosed acute myeloid leukemia. Sellar, Rob // Current Medical Literature: Leukemia & Lymphoma;2013, Vol. 21 Issue 1, p30 

  The article reviews a study of patients aged 65 years and older with newly diagnosed acute myeloid leukemia (AML) who separately received intensive therapy and epigenetic therapy in 2013. It states that there was no statistically significant difference between the groups on early mortality. The...

Read the Article