TITLE

CT coronary plaque burden in asymptomatic patients with familial hypercholesterolaemia

AUTHOR(S)
Neefjes, Lisan A.; ten Kate, Gert-Jan R.; Rossi, Alexia; Galema-Boers, Annette J.; Langendonk, Janneke G.; Weustink, Annick C.; Moelker, Adriaan; Nieman, Koen; Mollet, Nico R.; Krestin, Gabriel P.; Sijbrands, Eric J.; de Feyter, Pim J.
PUB. DATE
July 2011
SOURCE
Heart;Jul2011, Vol. 97 Issue 14, p1151
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective To determine the calcium score and coronary plaque burden in asymptomatic statin-treated patients with heterozygous familial hypercholesterolaemia (FH) compared with a control group of patients with low probability of coronary artery disease, having non-anginal chest pain, using CT. Design, setting and patients 101 asymptomatic patients with FH (mean age 53±7 years; 62 men) and 126 patients with non-anginal chest pain (mean age 56±7 years; 80 men) underwent CT calcium scoring and CT coronary angiography. All patients with FH were treated with statins during a period of 10±8 years before CT. The coronary calcium score and plaque burden were determined and compared between the two patient groups. Results The median total calcium score was significantly higher in patients with FH (Agatston score=87, IQR 5-367) than in patients with non-anginal chest pain (Agatston score=7, IQR 0-125; p<0.001). The overall coronary plaque burden was significantly higher in patients with FH (p<0.01). Male patients with FH, whose low-density lipoprotein cholesterol levels were reduced by statins below 3.0 mmol/l, had significantly less coronary calcium (p<0.01) and plaque burden (p=0.02). Conclusion The coronary plaque burden is high in asymptomatic middle-aged patients with FH despite intense statin treatment.
ACCESSION #
67704876

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics