TITLE

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN TABLETS: IT'S APPLICATION TO ROUTINE QUALITY CONTROL ANALYSIS

AUTHOR(S)
Kavitha, J.; Nagarajan, J. S. K.; Muralidharan, S.; Suresh, B.
PUB. DATE
October 2011
SOURCE
International Journal of Pharmacy & Pharmaceutical Sciences;Oct2011, Vol. 3 Issue 4, p113
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A very simple, rapid and sensitive RP-HPLC method has been developed and validated for the analysis of Telmisartan and Hydrochlorothiazide in tablet formulation. Best chromatographic resolution was achieved on a reverse-phase Princeton SPHER C18 column using acetonitrile: 50mM potassium dihydrogen ortho phosphate (pH 3.5) ratio 50:50 as mobile phase with a flow rate of 1mL/min and isocratic elution with a total run time of 10 minutes. Sulphadoxine was selected as internal standard. The retention time of Telmisartan, Hydrochlorothiazide and Internal Standard was found to be 4.71, 7.06 and 9.56 respectively. Detection of the multicompounds was carried out at 270nm. The present newly developed method was found to be accurate, precise and can be useful for routine Quality control analysis.
ACCESSION #
67703236

 

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