TITLE

Postconditioning Hormesis Put in Perspective: An Overview of Experimental and Clinical Studies

AUTHOR(S)
Wiegant, F. A. C.; Prins, H. A. B.; Van Wijk, R.
PUB. DATE
April 2011
SOURCE
Dose-Response;2011, Vol. 9 Issue 2, p209
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A beneficial effect of applying mild stress to cells or organisms, that were initially exposed to a high dose of stress, has been referred to as 'postconditioning hormesis'. The initial high dose of stress activates intrinsic self-recovery mechanisms. Modulation of these endogenous adaptation strategies by administration of a subsequent low dose of stress can confer effects that are beneficial to the biological system. Owing to its potentially therapeutic applications, postconditioning hormesis is subject to research in various scientific disciplines. This paper presents an overview of the dynamics of postconditioning hormesis and illustrates this phenomenon with a number of examples in experimental and clinical research.
ACCESSION #
67699264

 

Related Articles

  • Hormesis: Decoding Two Sides of the Same Coin. Bhakta-Guha, Dipita; Efferth, Thomas // Pharmaceuticals;2015, Vol. 8 Issue 4, p865 

    In the paradigm of drug administration, determining the correct dosage of a therapeutic is often a challenge. Several drugs have been noted to demonstrate contradictory effects per se at high and low doses. This duality in function of a drug at different concentrations is known as hormesis....

  • Demands of Transparency. Koppal, Tanuja // Genomics & Proteomics;Jul/Aug2004, Vol. 4 Issue 6, p7 

    Comments on the issue of drug prescriptions and drug dosage on children and adults. Queries on the disclosure of failed experiments in medicine research; Transparency on experimental results whether the outcome is negative or positive; Value of scientific courtesy.

  • Will drug-free therapy offer asthma relief? Baines, Emma // GP: General Practitioner;4/13/2007, p17 

    The article questions the effectiveness of the research that claims drug-free therapy for asthma patients. The therapy involves inserting a probe into the lungs and burning the muscle tissue, which is said to halves the risk of an asthma attack according to researchers. But, patients with severe...

  • Hormesis is central to toxicology, pharmacology and risk assessment. Calabrese, Edward J. // Human & Experimental Toxicology;Apr2010, Vol. 29 Issue 4, p249 

    This paper summarizes numerous conceptual and experimental advances over the past two decades in the study of hormesis. Hormesis is now generally accepted as a real and reproducible biological phenomenon, being highly generalized and independent of biological model, endpoint measured and...

  • Postconditioning hormesis and the homeopathic Similia principle: Molecular aspects. Van Wijk, R.; Wiegant, F. A. C. // Human & Experimental Toxicology;Jul2010, Vol. 29 Issue 7, p561 

    Postexposure conditioning, as a part of hormesis, involves the application of a low dose of stress following exposure to a severe stress condition. Depending on whether the low-dose stress is of the same type of stress or is different from the initial high-dose stress causing the diseased state,...

  • The Physiology of Fury. Galazka, Kasia // Psychology Today;Oct2010, Vol. 43 Issue 5, p16 

    The article describes the physiology of rage. An angry person usually clench his/her jaw to suppress emotion. While a man's larynx expands and his voice deepens when he is angry, women's voice on the other hand becomes shriller and high-pitched. To look more menacing, an angry person draws up...

  • Does acetylcysteine prevent contrast-induced renal dysfunction?  // Reactions Weekly;4/24/2004, Issue 998, p3 

    Focuses on an editorial published in the February 2004 issue of the "European Heart Journal," which comments on the contradictory findings of studies on the significance of acetylcysteine to the prevention of contrast-induced renal dysfunction. Difference in the dosages of acetylcysteine...

  • Dosimetry in leakage of [sup 188]Re-DTPA during intracoronary balloon brachytherapy. Jin Chul Paeng; Dong Soo Lee; Won Jun Kang; Han-Mo Yang; June-Key Chung; Jae Min Jeong; In-Ho Chae; Myoung-Mook Lee; Myung Chul Lee // European Journal of Nuclear Medicine & Molecular Imaging;2003, Vol. 30 Issue 9, p1263 

    Rhenium-188 is reported to he one of the best radionuclides for intracoronary balloon brachytherapy. Among several preparations of 188Re available for brachytherapy, 188Re-diethylene triamine penta-acetic acid (DTPA) and 188Re-mercaptoacetyltriglycine (MAG3) are recommended owing to their rapid...

  • Interaction of warfarin with glucosamine--chondroitin. Scott, Gayle Nicholas; Rozenfeld, Vitalina; Crain, Judy L.; Callahan, A. Kevin // American Journal of Health-System Pharmacy;6/1/2004, Vol. 61 Issue 11, p1186 

    This article presents a study investigating coagulation-related changes involving the interaction of warfarin with glucosamine. Researcher Crain Rozenfeld V. and his colleagues recently investigated certain coagulation-related changes in laboratory test values, such as International Normalized...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics