Structural characterization of a ribose-5-phosphate isomerase B from the pathogenic fungus Coccidioides immitis

January 2011
BMC Structural Biology;2011, Vol. 11 Issue 1, p39
Academic Journal
The article presents a study focusing on structural characterization of a ribose-5-phosphate isomerase B (RpiB) from the pathogenic fungus Coccidioides immitis. The study shows that C. immitis RpiB contains similar features as other members of this class of enzymes such as a highly reactive active site cysteine residue. It also states that C. immitis RpiB utilizes a divergent phosphate recognition strategy and may recognize a different substrate altogether.


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