TITLE

Regulation of nucleotide excision repair through ubiquitination

AUTHOR(S)
Li, Jia; Bhat, Audesh; Xiao, Wei
PUB. DATE
December 2011
SOURCE
Acta Biochimica et Biophysica Sinica;Dec2011, Vol. 43 Issue 12, p919
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Nucleotide excision repair (NER) is the most versatile DNA-repair pathway in all organisms. While bacteria require only three proteins to complete the incision step of NER, eukaryotes employ about 30 proteins to complete the same step. Here we summarize recent studies demonstrating that ubiquitination, a post-translational modification, plays critical roles in regulating the NER activity either dependent on or independent of ubiquitin-proteolysis. Several NER components have been shown as targets of ubiquitination while others are actively involved in the ubiquitination process. We argue through this analysis that ubiquitination serves to coordinate various steps of NER and meanwhile connect NER with other related pathways to achieve the efficient global DNA-damage response.
ACCESSION #
67627289

 

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