Structureï¿½Function Relationships in Heme-Proteins
- Identification of the Mitochondrial Heme Metabolism Complex. Medlock, Amy E.; Shiferaw, Mesafint T.; Marcero, Jason R.; Vashisht, Ajay A.; Wohlschlegel, James A.; Phillips, John D.; Dailey, Harry A. // PLoS ONE;8/19/2015, Vol. 10 Issue 8, p1
Heme is an essential cofactor for most organisms and all metazoans. While the individual enzymes involved in synthesis and utilization of heme are fairly well known, less is known about the intracellular trafficking of porphyrins and heme, or regulation of heme biosynthesis via protein...
- ON GLOBIN AND DENATURED GLOBIN. Holden, Henry Francis; Freeman, Mavis // Australian Journal of Experimental Biology & Medical Science;Sep1928, Vol. 5 Issue 3, p213
Describes the method for the preparation of globin. Evidence for the existence of compounds with certain porphyrins and their metallo-derivatives; Details on the process of denaturation of a protein; Limitation of the concentrations of denatured globin and hematin.
- 5-Aminolevulinic Acid. // Encyclopedic Reference of Cancer;2001, p41
A definition of the term "5-aminolevulinic acid" is presented. It refers to the precursor of protoporphyrin IX in the heme synthetic pathway. It is used as a photodiagnostic agent.
- Mechanisms of ligand discrimination by heme proteins. Jain, Rinku; Chan, Michael K. // Journal of Biological Inorganic Chemistry;Jan2003, Vol. 8 Issue 1/2, p1
Several classes of heme proteins have been identified whose primary role is to sense and transport one of the three gaseous ligands: O2, NO, or CO. A common feature shared by all of these proteins is the need to not only recognize its target ligand, but also discriminate against other heme...
- porphyria. // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1851
A definition of the term "porphyria," which refers to a group of disorders that result from a disturbance in any of the sequential steps involved in the synthesis of heme, causing increased formation and excretion of porphyrin or its precursors, is presented.
- Plesiomonas shigelloides hugZ encodes an iron-regulated heme binding protein required for heme iron utilization. Oldham, Athenia L.; Wood, Trisha A.; Henderson, Douglas P. // Canadian Journal of Microbiology;Feb2008, Vol. 54 Issue 2, p97
Plesiomonas shigelloides is an intestinal pathogen that uses heme as an iron source. The P. shigelloides heme utilization system consists of 10 genes, 7 of which permit heme transport and 3 of which are associated with utilization of heme as an iron source once it is inside the cell. The goal of...
- A heme tag for in vivo synthesis of artificial cytochromes. Braun, Martin; Rubio, Inés García; Thöny-Meyer, Linda // Applied Microbiology & Biotechnology;May2005, Vol. 67 Issue 2, p234
A genetic approach is described here that enables the specific covalent attachment of heme via a short C-terminal peptide tag to an otherwise non-heme-binding protein. Covalent attachment of heme to the apo-protein is catalysed by the cytochromecmaturation system ofEscherichia coli. While its...
- Neutral lipids associated with haemozoin mediate efficient and rapid Î²-haematin formation at physiological pH, temperature and ionic composition. Ambele, Melvin A; Egan, Timothy J // Malaria Journal;2012, Vol. 11 Issue 1, p337
Background: The malaria parasite disposes of host-derived ferrihaem (iron(III)protoporphyrin IX, Fe(III)PPIX) by conversion to crystalline haemozoin in close association with neutral lipids. Lipids mediate synthetic haemozoin (Î²-haematin) formation very efficiently. However, the effect on...
- Protoporphyrin IX. // Encyclopedic Reference of Cancer;2001, p733
A definition of the term "protoporphyrin IX" is presented. It refers to a naturally occurring fluorophore. Protoporphyrin IX is the immediate precursor of heme in the heme-synthetic pathway and may be used to detect neoplasia by fluorescence. Its concentration in neoplastic tissue may be...