Heme Oxygenase and the Kidney
- Acute lead exposure induces renal haeme oxygenase-1 and decreases urinary Na[sup +] excretion. Vargas, Hilda; Castillo, Carlos; Posadas, Francisco; Escalante, Bruno // Human & Experimental Toxicology;May2003, Vol. 22 Issue 5, p237
The effects of acute lead exposure on renal function, lipid peroxidation and the expression of haeme oxygenase (HO) in rat kidney were determined. A single injection of lead acetate (50 mg Pb/kg) was given to rats. Changes in renal function, characterized by a significant reduction in the Na[sup...
- Preconditioning with tin-protoporphyrin IX attenuates ischemia/reperfusion injury in the rat kidney. Kaizu, Takashi; Tamaki, Tohru; Tanaka, Mitsuko; Uchida, Yasushi; Tsuchihashi, Sei-Ichiro; Kawamura, Akio; Kakita, Akira // Kidney International;Apr2003, Vol. 63 Issue 4, p1393
Background:Heme oxygenase (HO)-1 is induced as a unique stress response and leads to a transient resistance against oxidative damage, including ischemia and reperfusion (I/R) injury. In the present study, we examined whether HO-1 induction may confer a protection against I/R injury...
- Heme oxygenase isoform-specific expression and distribution in the rat kidney. Da Silva, Jean-Louis; Zand, Barbara A.; Yang, Li Ming; Sabaawy, Hatem E.; Lianos, Elias; Abraham, Nader G.; da Silva, J L; Zand, B A; Yang, L M; Sabaawy, H E; Lianos, E; Abraham, N G // Kidney International;Apr2001, Vol. 59 Issue 4, p1448
Heme oxygenase isoform-specific expression and distribution in the rat kidney. Background. The heme oxygenase (HO) genes, HO-1 and HO-2 , are the limiting steps in heme degradation and in the regulation of renal heme-dependent enzymes. Previously we reported that selective overexpression of...
- Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases. Morimoto, Kayoko; Ohta, Kazuhide; Yachie, Akihiro; Yang, Yonghong; Shimizu, Masaki; Goto, Chinami; Toma, Tomoko; Kasahara, Yoshihito; Yokoyama, Hitoshi; Miyata, Toshio; Seki, Hidetoshi; Koizumi, Shoichi; Morimoto, K; Ohta, K; Yachie, A; Yang, Y; Shimizu, M; Goto, C; Toma, T; Kasahara, Y // Kidney International;Nov2001, Vol. 60 Issue 5, p1858
Background:We previously reported that glomerular changes in the renal specimen of a human case with heme oxygenase-1 (HO-1) deficiency were mild, but tubulointerstitial injury advanced progressively. This study examined the patterns of HO-1 production in the kidney in various...
- 3,4,5-Trihydroxycinnamic acid increases heme-oxygenase-1 (HO-1) and decreases macrophage infiltration in LPS-induced septic kidney. Lee, Jae-Won; Kwon, Jae-Hyun; Lim, Man; Lee, Hee; Kim, Sung-Soo; Chun, Wanjoo; Lim, So // Molecular & Cellular Biochemistry;Dec2014, Vol. 397 Issue 1/2, p109
We previously demonstrated that 3,4,5-trihydorxycinnamic acid (THC), a derivative of hydroxycinnamic acids, possesses protective effect in lipopolysaccharide (LPS)-induced endotoxemia models. However, the effects of THC in LPS-induced septic kidney are still unclear. Therefore, the present study...
- Heme oxygenase-1 in renal injury: conclusions of studies in humans and animal models. Kanwar, Yashpal S.; Kanwar, Y S // Kidney International;Jan2001, Vol. 59 Issue 1, p378
Editorial. Comments on the catabolism of heme to biliverdin by heme oxygenase. Identification on three isoenzymes of heme oxygenase; Expression of HO-1 and ferritin; Focus on monocyte chemoattractant peptide.
- heme oxygenase. // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1037
A definition of the term "heme oxygenase," which refers to an enzyme that cleaves the ring structure of heme, releasing biliverdin, carbon monoxide, and iron, is presented.
- HO-1 Attenuates Hypertension-Induced Inflammation/Oxidative Stress: Support From Bartter's/Gitelman's Patients. Cal&ò, Lorenzo A.; Fusaro, Maria; Davis, Paul A. // American Journal of Hypertension;Sep2010, Vol. 23 Issue 9, p936
A letter to the editor is presented in response to the article "Celastrol Attenuates Hypertension-Induced Inflammation and Oxidative Stress in Vascular Smooth Muscle Cells via Induction of Heme Oxygenase-1," by X. Yu and colleagues in the 2010 issue.
- The Biology of Bilirubin Production. Dennery, Phyllis A; Weng, Yi-Hao; Stevenson, David K; Yang, Guang // Journal of Perinatology;Dec2001 Supplement 1, Vol. 21 Issue 8, pS17
Heme oxygenase (HO), the rate-limiting enzyme in bilirubin production, has been identified from the late 1960s. This enzyme has been shown to have many other roles in recent years. The inducible form is regulated by oxidative stress, inflammation, and heavy metals, among others, and is...