TITLE

Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer

AUTHOR(S)
Carpenter, B.; McKay, M.; Dundas, S. R.; Lawrie, L. C.; Telfer, C.; Murray, G. I.
PUB. DATE
October 2006
SOURCE
British Journal of Cancer;10/9/2006, Vol. 95 Issue 7, p921
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Heterogeneous ribonucleoprotein K (hnRNP K) is a member of the hnRNP family which has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis, for instance hnRNP K increases transcription of the oncogene c-myc and hnRNP K expression is regulated by the p53/MDM 2 pathway. In this study comparing normal colon to colorectal cancer by proteomics, hnRNP K was identified as being overexpressed in this type of cancer. Immunohistochemistry with a monoclonal antibody to hnRNP K (which we developed) on colorectal cancer tissue microarray, confirmed that hnRNP K was overexpressed in colorectal cancer (P<0.001) and also showed that hnRNP K had an aberrant subcellular localisation in cancer cells. In normal colon hnRNP K was exclusively nuclear whereas in colorectal cancer the protein localised both in the cytoplasm and the nucleus. There were significant increases in both nuclear (P=0.007) and cytoplasmic (P=0.001) expression of hnRNP K in Dukes C tumours compared with early stage tumours. In Dukes C patient's good survival was associated with increased hnRNP K nuclear expression (P=0.0093). To elaborate on the recent observation that hnRNP K is regulated by p53, the expression profiles of these two proteins were also analysed. There was no correlation between hnRNP K and p53 expression, however, patients who presented tumours that were positive for hnRNP K and p53 had a poorer survival outcome (P=0.045).British Journal of Cancer (2006) 95, 921–927. doi:10.1038/sj.bjc.6603349 www.bjcancer.com Published online 5 September 2006
ACCESSION #
67542907

 

Related Articles

  • Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. Carpenter, B.; McKay, M.; Dundas, S. R.; Lawrie, L. C.; Telfer, C.; Murray, G. I. // British Journal of Cancer;10/9/2006, Vol. 95 Issue 7, p921 

    Heterogeneous ribonucleoprotein K (hnRNP K) is a member of the hnRNP family which has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis, for instance hnRNP K increases...

  • Colorectal cancer screening.  // Patient Care;9/15/1997, Vol. 31 Issue 14, p19 

    States that an average of 155,000 cases of colorectal cancer is diagnosed each year in the United States. What government is doing to alleviate the problem; Reference to recommendations being made by the United States Preventive Services Task Force; Effects of the approaches being used by the...

  • Right or left, right or wrong? Debate whirls over colorectal cancer distribution. Milne, David // JNCI: Journal of the National Cancer Institute;10/5/94, Vol. 86 Issue 19, p1442 

    Reports on the debate concerning the change in colorectal cancer distribution. Identification of tumors in the distal portion of the bowel; Data on the review of cases of colon and rectum cancer diagnosed from 1937 to 1948 at the Massachusetts General Hospital; Finding of right hand lesions.

  • Low Percentage of KRAS Mutations Revealed by Locked Nucleic Acid Polymerase Chain Reaction: Implications for Treatment of Metastatic Colorectal Cancer. Dono, Mariella; Massucco, Carlotta; Chiara, Silvana; Sonaglio, Claudia; Mora, Marco; Truini, Anna; Cerruti, Giannamaria; Zoppoli, Gabriele; Ballestrero, Alberto; Truini, Mauro; Ferrarini, Manlio; Zupo, Simona // Molecular Medicine;dec2012, Vol. 18 Issue 12, p1519 

    Metastatic colorectal cancer (mCRC) is frequently characterized by the presence of mutations of the KRAS oncogene, which are generally associated with a poor response to treatment with anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies. With the methods currently used, a...

  • NTRK3 Is a Potential Tumor Suppressor Gene Commonly Inactivated by Epigenetic Mechanisms in Colorectal Cancer. Luo, Yanxin; Kaz, Andrew M.; Kanngurn, Samornmas; Welsch, Piri; Morris, Shelli M.; Wang, Jianping; Lutterbaugh, James D.; Markowitz, Sanford D.; Grady, William M. // PLoS Genetics;Jul2013, Vol. 9 Issue 7, p1 

    NTRK3 is a member of the neurotrophin receptor family and regulates cell survival. It appears to be a dependence receptor, and thus has the potential to act as an oncogene or as a tumor suppressor gene. NTRK3 is a receptor for NT-3 and when bound to NT-3 it induces cell survival, but when NT-3...

  • Quick Review: Cancer Of The Large Intestine. Phillips, Bradley J.; Perry, Charles W. // Internet Journal of Gastroenterology;2002, Vol. 1 Issue 2, p10 

    150,000 new cases of Colorectal CA are diagnosed each year in the United States and 60,000 people die of this disease annually. The actual incidence increases with age: at dge 50, 0.39 per 1000 persons/yr; at age 80, 4.5 per 1000 persons/yr. Carcinoma of the colon (particularly the right side)...

  • ω3 Polyunsaturated Fatty Acids as immunomodulators in Colorectal Cancer: new Potential Role in Adjuvant Therapies. Miccadei, Stefania; Masella, Roberta; Mileo, Anna Maria; Gessani, Sandra // Frontiers in Immunology;11/15/2016, Vol. 7, p1 

    Diet composition may affect the onset and progression of chronic degenerative diseases, including cancer, whose pathogenesis relies on inflammatory processes. Growing evidence indicates that diet and its components critically contribute to human health, affecting the immune system, secretion of...

  • Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature. Lorenzon, Laura; Ferri, Mario; Pilozzi, Emanuela; Torrisi, Maria; Ziparo, Vincenzo; French, Deborah // International Journal of Colorectal Disease;Feb2011, Vol. 26 Issue 2, p135 

    Purpose: The aim of this study is to review published literature regarding a possible role of human papillomavirus (HPV) infection in colorectal cancer in order to understand if HPV infection plays an active role in colorectal carcinogenesis and to highlight evidences and pitfalls of published...

  • A deterministic model for estimating the reduction in colorectal cancer incidence due to endoscopic surveillance. Cafferty, Fay H.; Sasieni, Peter D.; Duffy, Stephen W. // Statistical Methods in Medical Research;Apr2009, Vol. 18 Issue 2, p163 

    There is evidence that the removal of adenomas, by endoscopy, from the large bowel can prevent the occurrence of colorectal cancer (CRC). However, the reduction in cancer incidence due to endoscopic surveillance is difficult to estimate. Studies of cohorts of adenoma patients typically rely on...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics