TITLE

Restrictive extraocular myopathy: A presenting feature of acromegaly

AUTHOR(S)
Heireman, Steven; Delaey, Christophe; Claerhout, Ilse; Decock, Christian E.
PUB. DATE
November 2011
SOURCE
Indian Journal of Ophthalmology;Nov2011, Vol. 59 Issue 6, p517
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A 45-year-old man presented with binocular diplopia in primary gaze for 1 year. Orthoptic evaluation showed 10-prism diopter right eye hypotropia and 6-prism diopter right eye esotropia. The elevation and abduction of the right eye were mechanically restricted. This was associated with systemic features suggestive of acromegaly. Magnetic resonance imaging (MRI) of the brain demonstrated a pituitary macroadenoma. An elevated serum insulin-like growth factor I level and the failure of growth hormone suppression aft er an oral glucose load biochemically confi rmed the diagnosis of acromegaly. Computed tomography (CT) of the orbit demonstrated bilateral symmetrical enlargement of the medial rectus and inferior rectus muscle bellies. All tests regarding Graves-Basedow disease were negative. Although rare, diplopia due to a restrictive extraocular myopathy could be the presenting symptom of acromegaly.
ACCESSION #
67520127

 

Related Articles

  • Familial Acromegaly. Yarman, Sema // Journal of Clinical Research in Pediatric Endocrinology;2015 Supplement, Vol. 7, p34 

    An abstract of the article regarding the familial growth hormone (GH)-secreting pituitary adenoma also called as familial somatotropinoma (FS) or familial acromegaly is presented.

  • Muscle changes in acromegaly. Nagulesparen, M.; Trickey, R.; Davies, M.J. // British Medical Journal;10/16/1976, Vol. 2 Issue 6041, p914 

    Examines the abnormalities of muscle of patients with acromelagy. Significance of the abnormalities with the plasma levels of growth hormone; Efforts for studying muscle by needle biopsy; Effectiveness of the needle biopsy for determining the natural history of acromelagic myopathy.

  • An update on the treatment of acromegaly. Edling, Kari L.; Heaney, Anthony P. // Research & Reports in Endocrine Disorders;2013, Vol. 3, p1 

    Acromegaly is caused by pituitary somatotroph hypersecretion of growth hormone leading to elevated hepatic-derived and local levels of insulin-like growth factor-1. It is associated with increased morbidity and mortality due primarily to cardiovascular disease and diabetes mellitus....

  • Pegvisomant.  // Reactions Weekly;8/23/2008, Issue 1216, p28 

    The article describes the case of a 33-year-old woman with acromegaly who developed subcutaneous lipoatrophy with subsequent impairment of drug absorption and effectiveness during treatment with pegvisomant. She started receiving pegvisomant in combination with octreotide. The skin of both her...

  • TREATMENT OF GH DEFICIENCY IN ADULTS GROWTH HORMONE IS THE MOST FREQUENT PITUITARY HORMONE DEFICIT AND IS AFFECTED FIRST. Popovic, V. // Problemy Endokrinologii;2017 Supplement, p9 

    Hypopituitarism results from complete or partial defi ciency of pituitary hormones and is caused by a variety of structural lesions or trauma involving the hypothalamus or pituitary gland (most often pituitary adenomas). There is a varying sensitivity of the diff erent anterior pituitary...

  • A CASE REPORT OF PITUITARY GIGANTISM OF 27-YEAR-OLD MALE PATIENT IN CHELYABINSK REGION OF RUSSIA. Zheleznyakova, Anna; Rostomyan, Liliya; Belaya, Zhanna // Problemy Endokrinologii;2017 Supplement, p23 

    Pituitary gigantism is a rare disorder. It refers to growth hormone (GH) excess that occurs before fusion of the epiphyseal growth plates. We report a 27-year-old male patient with a pituitary macroadenoma who underwent transsphenoidal surgery in 2004 at the age of 15 with the height up to 215...

  • THE CASE OF TSH-PRODUCTION PITUITARY ADENOMA WITH LATE DIAGNOSIS. Garaskova, Lidia // Problemy Endokrinologii;2017 Supplement, p28 

    A pituitary adenoma is frequent endocrine pathology. It more commons in women. The fi rst place of hormone- activity adenoma belongs to prolactinoma, the second place — somatotropinoma. The TSH-production adenoma is very rare type of hormone- pituitary neoplasias. In the report we will...

  • TRANSFORMATION OF PROLACTINOMA INTO CORTICOTROPIN-SECRETING ADENOMA IN PATIENT WITH MEN 1 SYNDROME: A CASE REPORT. Rozhinskaya, Ludmila; Belaya, Zhanna; Khandaeva, Patimat // Problemy Endokrinologii;2017 Supplement, p35 

    Multiple endocrine neoplasia syndrome type 1 (MEN 1 type, Wermer's syndrome) is a group of heterogeneous inherited diseases, pathogenesis of which is based on hyperplasia or neoplasia of several endocrine glands, characterized by autosomal dominant mode of inheritance, high penetrance and...

  • Acromegaly: Treatment by Cryoablation. Maddy, James A.; Winternitz, William W.; Norrel, Horace; Quellen, Donald; Wilson, Charles B. // Annals of Internal Medicine;Sep69, Vol. 71 Issue 3, p497 

    Presents a study which examined the results of cryoablation of pituitary adenomas in patients with acromegaly. Patients and methods; Results; Discussion.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics