Medication use in relation to noise from aircraft and road traffic in six European countries: results of the HYENA study

Floud, Sarah; Vigna-Taglianti, Federica; Hansell, Anna; Blangiardo, Marta; Houthuijs, Danny; Breugelmans, Oscar; Cadum, Ennio; Babisch, Wolfgang; Selander, Jenny; Pershagen, Gör4an; Antoniotti, Maria Chiara; Pisani, Salvatore; Dimakopoulou, Konstantina; Haralabidis, Alexandros S; Velonakis, Venetia; Jarup, Lars
July 2011
Occupational & Environmental Medicine;Jul2011, Vol. 68 Issue 7, p518
Academic Journal
Objectives Studies on the health effects of aircraft and road traffic noise exposure suggest excess risks of hypertension, cardiovascular disease and the use of sedatives and hypnotics. Our aim was to assess the use of medication in relation to noise from aircraft and road traffic. Methods This cross-sectional study measured the use of prescribed antihypertensives, antacids, anxiolytics, hypnotics, antidepressants and antasthmatics in 4,861 persons living near seven airports in six European countries (UK, Germany, the Netherlands, Sweden, Italy, and Greece). Exposure was assessed using models with 1dB resolution (5dB for UK road traffic noise) and spatial resolution of 250 &;250m for aircraft and 10 &;10m for road traffic noise. Data were analysed using multilevel logistic regression, adjusting for potential confounders. Results We found marked differences between countries in the effect of aircraft noise on antihypertensive use; for night-time aircraft noise, a 10dB increase in exposure was associated with ORs of 1.34 (95% CI 1.14 to1.57) for the UK and 1.19 (1.02 to 1.38) for the Netherlands but no significant associations were found for other countries. For day-time aircraft noise, excess risks were found for the UK (OR 1.35; CI: 1.13 to 1.60) but a risk deficit for Italy (OR 0.82; CI: 0.71 to 0.96). There was an excess risk of taking anxiolytic medication in relation to aircraft noise (OR 1.28; CI: 1.04 to 1.57 for daytime and OR 1.27; CI: 1.01 to 1.59 for night-time) which held across countries. We also found an association between exposure to 24hr road traffic noise and the use of antacids by men (OR 1.39; CI 1.11 to 1.74). Conclusion Our results suggest an effect of aircraft noise on the use of antihypertensive medication, but this effect did not hold for all countries. Results were more consistent across countries for the increased use of anxiolytics in relation to aircraft noise.


Related Articles

  • Use of tranquilizers and sleeping pills among cancer patients is associated with a poorer quality of life. Paltiel, O.; Marzec-Boguslawska, A.; Soskolne, V.; Massaiha, S.; Avitzour, M.; Pfeffer, R.; Cherny, N.; Peretz, T.; Massalha, S // Quality of Life Research;Dec2004, Vol. 13 Issue 10, p1699 

    Purpose: To evaluate the association between sleeping pill/tranquilizer (SP/T) use and quality of life (QOL) among cancer patients.Patients and Methods: Oncology patients (n = 909) in three Israeli hospitals were interviewed in clinics, day centers and in-patient...

  • Benzodiazepines on trial. Tyrer, P.J. // British Medical Journal (Clinical Research Edition);4/14/1984, Vol. 288 Issue 6424, p1101 

    Examines the efficacy of benzodiazepines as an antianxiety drugs and hypnotics. Occurrence of pharmacological dependence on therapeutic dosage; Production of perceptual disturbance; Management of benzodiazepine dependence.

  • In adults, use of anxiolytic or hypnotic drugs was associated with increased risk for mortality. Belknap, Steven M. // Annals of Internal Medicine;7/15/2014, Vol. 161 Issue 2, pJC11 

    A review for the article "Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study" by S. Weich and others published in a 2014 issue of the periodical "British Medical Journal" is presented.

  • Increased prevalence of hypertension in a population exposed to aircraft noise. Rosenlund, M.; Berglind, N.; Pershagen, G.; Jarup, L.; Bluhm, G. // Occupational & Environmental Medicine;Dec2001, Vol. 58 Issue 12, p769 

    Presents a study that investigated whether there is a relation between residential exposure to aircraft noise and hypertension. Prevalence of hypertension among residents with exposure to equal energy and maximum levels of aircraft noise in Stockholm county; Background on links between aircraft...

  • Study of the Anxiolytic Activity of Captopril Against the Anxiogenic Potential of Ciprofloxacin in Different Models of Anxiety in Rats. Ahmed, H. I.; Ezzeldin, E. // Australian Journal of Basic & Applied Sciences;2011, Vol. 5 Issue 9, p738 

    Captopril is a widely used ACE inhibitor for treatment of arterial hypertension and cardiovascular diseases. It has been shown experimentally to exert anxiolytic activity both in normotensive and hypertensive rats. Ciprofloxacin, a benchmark for comparing the efficacy of new fluoroquinolones and...

  • Saudi Arabia curbs tranquilliser prescribing. Kandela, Peter // BMJ: British Medical Journal (International Edition);2/3/96, Vol. 312 Issue 7026, p271 

    Reports on the call to curb the excessive prescribing of tranquilizers and hypnotics in Saudi Arabia. Concerns on possible epidemic of drug misuse; Speculations on the use of tranquilizers and hypnotics in Saudi Arabia.

  • The Clinical Choice of Sedative-Hypnotics. Greenblatt, David J. // Annals of Internal Medicine;Jul72, Vol. 77 Issue 1, p91 

    Focuses on three antidepressant drugs, sedatives, hypnotics and tranquilizer. Differences of hypnotics from tranquilizers; Considerations on which to base the choice of hypnotic drug; Differences in pharmacology of tranquilizers and sedative-hypnotics.

  • Tenoten in the Therapy of Anxious Disturbances in Patients with Essential Hypertension and Coronary Heart Disease. Vanchakova, N.; Popov, A. // Bulletin of Experimental Biology & Medicine;Aug2009, Vol. 148 Issue 2, p343 

    The study demonstrated high anxiolytic activity of tenoten, which was not inferior to the anxiolytic effect of grandaxin. The positive changes persisted after termination of treatment in the tenoten group (but not in grandaxin group). Tenoten can be recommended for the treatment of patients with...

  • Aircraft noise around a large international airport and its impact on general health and medication use. Franssen, E. A. M.; Van Wiechen, C. M. A. G.; Nagelkerke, N. J. D.; Lebret, E. // Occupational & Environmental Medicine;May2004, Vol. 61 Issue 5, p405 

    Aims: To assess the prevalence of general health status, use of sleep medication, and use of medication for cardiovascular diseases, and to study their relation to aircraft noise exposure. Methods: These health indicators were measured by a cross-sectional survey among 11 812 respondents living...


Read the Article


Sign out of this library

Other Topics