Current Status of Endomyocardial Biopsy

November 2011
Mayo Clinic Proceedings;Nov2011, Vol. 86 Issue 11, p1095
Academic Journal
Endomyocardial biopsy (EMB) is widely used for surveillance of cardiac allograft rejection and for the diagnosis of unexplained ventricular dysfunction. Typically, EMB is performed through the jugular or femoral veins and is associated with a serious acute complication rate of less than 1% using current flexible bioptomes. Although it is accepted that EMB should be used to monitor for rejection after transplant, use of EMB for the diagnosis of various myocardial diseases is controversial. Diagnosis of myocardial disease in the nontransplant recipient is often successful via noninvasive investigations including laboratory evaluation; echocardiography, nuclear studies, and magnetic resonance imaging can yield specific diagnoses in the absence of invasive EMB. Therefore, use of the technique is patient specific and depends on the potential prognostic and treatment information gained by establishing a pathologic diagnosis beyond noninvasive testing.


Related Articles

  • Assessment of sub-clinical acute cellular rejection after heart transplantation: comparison of cardiac magnetic resonance imaging and endomyocardial biopsy. Krieghoff, Christian; Barten, Markus; Hildebrand, Lysann; Grothoff, Matthias; Lehmkuhl, Lukas; Lücke, Christian; Andres, Claudia; Nitzsche, Stefan; Riese, Franziska; Strüber, Martin; Mohr, Friedrich; Gutberlet, Matthias // European Radiology;Oct2014, Vol. 24 Issue 10, p2360 

    Objective: Comparing the diagnostic value of multi-sequential cardiac magnetic resonance imaging (CMR) with endomyocardial biopsy (EMB) for sub-clinical cardiac allograft rejection. Methods: One hundred and forty-six examinations in 73 patients (mean age 53 ± 12 years, 58 men) were performed...

  • Cardiovascular magnetic resonance in the diagnosis of acute heart transplant rejection: a review. Butler, Craig R.; Thompson, Richard; Haykowsky, Mark; Toma, Mustafa; Paterson, Ian // Journal of Cardiovascular Magnetic Resonance (BioMed Central);2009, Vol. 11, p1 

    Background: Screening for organ rejection is a critical component of care for patients who have undergone heart transplantation. Endomyocardial biopsy is the gold standard screening tool, but noninvasive alternatives are needed. Cardiovascular magnetic resonance (CMR) is well suited to provide...

  • Partial Anomalous Pulmonary Venous Return in a Patient With Turner Syndrome. Mir, Arshid; Guleserian, Kristine; Barnes, Aliessa; Blalock, Shannon // Pediatric Cardiology;Feb2011, Vol. 32 Issue 2, p237 

    The article presents a case study of a 2-year-old patient with partial anomalous pulmonary venous return (PAPVR) and Turner Syndrome (XO), hypoplastic kidneys, hydronephrosis and gonadal dysgenesis. It notes that cardiac magnetic resonance imaging (MRI) asserted the findings of echocardiogram...

  • Everolimus.  // Reactions Weekly;2/23/2008, Issue 1190, p13 

    The article describes the case of a 44-year-old male patient who had a huge right atrial thrombus 6 years after heart transplantation. After the heart transplant, the patient' immunosuppressive regimen was changed from ciclosporin to everolimus. Since the change in regimen, his condition rapidly...

  • Magnetic Resonance Imaging in Breast Cancer: One Step Forward, Two Steps Back? Morrow, Monica // JAMA: Journal of the American Medical Association;12/8/2004, Vol. 292 Issue 22, p2779 

    Presents the authors thoughts on the use of magnetic resonance imaging (MRI) for the detection of breast cancer. Questions the reason for the increase in the use of MRI to preclude the need for surgical biopsy; Details of the International Breast Magnetic Resonance Consortium.

  • An approach to endomyocardial biopsy interpretation. Cunningham, K. S.; Veinot, J. P.; Butany, J. // Journal of Clinical Pathology;Feb2006, Vol. 59 Issue 2, p121 

    The endomyocardial biopsy (EMB) remains the gold standard mode of investigation for diagnosing many primary and secondary cardiac conditions. Through a percutaneous and transvenous route, tissue fragments are generally procured from the right ventricular septum, with very few complications....

  • Characterisation of peripartum cardiomyopathy by cardiac magnetic resonance imaging. Mouquet, Frederic; Lions, Christophe; Groote, Pascal; Bouabdallaoui, Nadia; Willoteaux, Serge; Dagorn, Joel; Deruelle, Philippe; Lamblin, Nicolas; Bauters, Christophe; Beregi, Jean // European Radiology;Dec2008, Vol. 18 Issue 12, p2765 

    Peripartum cardiomyopathy (PPCM) is a rare cause of heart failure. Only half of the patients recover normal cardiac function. We assessed the usefulness of magnetic resonance imaging (MRI) and late enhancement imaging to detect myocardial fibrosis in order to predict cardiac function recovery in...

  • 'Honeycomb appearance' on three-dimensional transthoracic echocardiography as the landmark of left ventricular non-compaction: two case reports. Takao Konishi; Tomoo Nagai; Akira Hamabe; Junko Arakawa; Hideki Hisadome; Mikoto Yoshida; Hirotsugu Tabata // Journal of Medical Case Reports;2013, Vol. 7 Issue 1, p1 

    Introduction: Left ventricular non-compaction is a rare congenital heart disease, and is most commonly diagnosed via two-dimensional echocardiography according to echocardiographic criteria. Recently, transthoracic threedimensional echocardiography has become available in the clinical setting....

  • Multidisciplinary assessment of tako tsubo cardiomyopathy: a prospective case study. Waldenborg, Micael; Soholat, Mona; Kähäri, Anders; Emilsson, Kent; Fröbert, Ole // BMC Cardiovascular Disorders;2011, Vol. 11 Issue 1, p14 

    Background: The cause of tako tsubo cardiomyopathy remains unclear. We used a multi disciplinary approach to investigate if a common pathophysiological denominator could be outlined. Methods: Within 3 days following symptom presentation and again after 3 months we investigated all patients...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics