Standardizing i.v. infusion concentrations: National survey results

November 2011
American Journal of Health-System Pharmacy;11/15/2011, Vol. 68 Issue 22, p2176
Academic Journal
Purpose. The results of a 2008 survey by the U.S. Pharmacopeia (USP) Safe Medication Use Expert Committee assessing the use of standardized i.v. drug concentrations at U.S. health care institutions are presented. Methods. To evaluate progress toward the goal of standardizing and limiting the number of i.v. infusion concentrations of high-risk medications, particularly those commonly used in pediatric patients, a USP-appointed expert committee surveyed a nationally representative sample of hospital and health-system pharmacy directors; 229 usable survey responses and 174 requested lists of routinely used or "standard" concentrations (i.e., those designed to meet the needs of at least 90% of the target adult, pediatric, and neonatal populations) were received. Results. The survey responses indicated that multiple concentrations of high-risk drugs are still commonly used; in some instances, as many as four standard concentrations of a single medication were reported to be in use for a particular age group. Depending on the drug and target group, the proportion of respondents reporting the use of one standard concentration for a given drug ranged from 15% to 79%. The survey data informed and helped focus the USP expert committee's efforts to develop recommended standard concentrations for 10 high-alert drugs. Also presented in this article are general principles drafted by the USP committee to guide the development of local and national standard concentrations. Conclusion. The results of a national USP survey indicate that many institutions do not use standard i.v. infusion concentrations of commonly used high-risk medications in adult, pediatric, or neonatal patient populations.


Related Articles

  • Inadvertent intrathecal administration of vincristine: Has anything changed? Gilbar, Peter // Journal of Oncology Pharmacy Practice;Mar2012, Vol. 18 Issue 1, p155 

    The author reflects on the inadvertent intrathecal administration of vincristine. He suggests that every error involving the administration of a vinca alkaloid into the spinal fluid over the past 40 years has occurred when the drug was prepared in a syringe. He argues that medical personnel need...

  • Pharmacokinetics, safety, and tolerability of a rapid infusion of i.v. ibuprofen in healthy adults. Pavliv, Leo; Voss, Bryan; Rock, Amy // American Journal of Health-System Pharmacy;1/1/2011, Vol. 68 Issue 1, p47 

    Purpose. The pharmacokinetics, safety, and tolerability of a rapid infusion of i.v. ibuprofen in healthy adults were evaluated. Methods. In this randomized, doubleblind, placebo-controlled, single-dose, crossover study, 12 healthy subjects age 18-65 years were randomized to receive a single dose...

  • ASHP Guidelines on Home Infusion Pharmacy Services.  // American Journal of Health-System Pharmacy;2/15/2014, Vol. 71 Issue 4, p325 

    The article presents the "ASHP Guidelines on Home Infusion Pharmacy Services," released by the American Society of Health-System Pharmacists (ASHP). It discusses the background and purpose of home infusion services, as well as elaborates on the mission of the home infusion organization, and the...

  • lock, saline.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1360 

    A definition of the term "lock, saline," which refers to an intravenous portal used for medication infusions, is presented.

  • Lean methodology in i.v. medication processes in a children's hospital. L'Hommedieu, Timothy; Kappeler, Karl // American Journal of Health-System Pharmacy;12/15/2010, Vol. 67 Issue 24, p2115 

    Purpose. The impact of lean methodology in i.v. medication processes in a children's hospital was studied. Methods. Medication orders at a children's hospital were analyzed for 30 days to identify the specific times when most medications were changed or discontinued. Value-stream mapping was...

  • Addressing challenges in bar-code scanning of large-volume infusion bags. Raman, Kirthana; Heelon, Mark; Kerr, Gary; Higgins, Thomas L. // American Journal of Health-System Pharmacy;8/1/2011, Vol. 68 Issue 15, p1450 

    Purpose. A hospital pharmacy's efforts to identify and address challenges with bedside scanning of bar codes on large-volume parenteral (LVP) infusion bags are described. Summary. Bar-code-assisted medication administration (BCMA) has been shown to reduce medication errors and improve patient...

  • Target-controlled infusion systems: role in anaesthesia and analgesia. van den Nieuwenhuyzen, M.C.; Engbers, F.H.M.; Vuyk, J.; Burm, A.G.; Engbers, F H // Clinical Pharmacokinetics;2000, Vol. 38 Issue 2, p181 

    Drug delivery by target-controlled infusion (TCI) allows automatic adjustments of the infusion rate of a drug to maintain a desired target concentration. Since drug effect is more closely related to blood concentration than to infusion rate, drug delivery via TCI is capable of creating stable...

  • Development and Implementation of Standardized Intravenous Immune Globulin Orders for Pediatric Patients. Speight, Kathy Palmer; Zillmer, Rhonda H.; Alexander, Benjamin S.; Yeakey, Anne M. // Hospital Pharmacy;Jan2006, Vol. 41 Issue 1, p38 

    Purpose: To develop and implement a standardized intravenous immune globulin (IVIG) order set for pediatric patients in a community hospital. Methods: Standardized orders are used in many hospitals to help guide the medication ordering process. WakeMed Health and Hospitals in Raleigh, North...

  • I.V. batching improvements cited in Baldrige win. Traynor, Kate // American Journal of Health-System Pharmacy;2/1/2016, Vol. 73 Issue 3, p104 

    The article reports that Charleston Area Medical Center (CAMC) Health System in West Virginia credits improvements in intravenous medication preparation for its winning of the 2015 Malcolm Baldrige National Quality Award for healthcare. Topics covered include CAMC pharmacy director Brian Sayre's...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics