Effects of formoterol on histamine induced plasma exudation in induced sputum from normal subjects

Greiff, Lennart; Wollmer, Per; Andersson, Morgan; Svensson, Christer; Persson, Carl G. A.
December 1998
Thorax;Dec1998, Vol. 53 Issue 12, p1010
Academic Journal
No abstract available.


Related Articles

  • Effects of formoterol-budesonide on airway remodeling in patients with moderate asthma. Wang, Ke; Liu, Chun-tao; Wu, Yong-hong; Feng, Yu-lin; Bai, Hong-li; Ma, En-sen; Wen, Fu-qiang // Acta Pharmacologica Sinica;Jan2011, Vol. 32 Issue 1, p126 

    Aim:To evaluate the effect of inhaled formoterol-budesonide on airway remodeling in adult patients with moderate asthma.Methods:Thirty asthmatic patients and thirty control subjects were enrolled. Asthmatic subjects used inhaled Symbicort 4.5/160 μg twice daily for one year. The effect of...

  • Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses. Bochkov, Yury A.; Busse, William W.; Brockman-Schneider, Rebecca A.; Evans, Michael D.; Jarjour, Nizar N.; McCrae, Christopher; Miller-Larsson, Anna; Gern, James E. // Respiratory Research;Oct2013, Vol. 14 Issue 10, p1 

    Background: Combination therapy with budesonide and formoterol reduces exacerbations of asthma, which are closely associated with human rhinovirus (RV) infections in both children and adults. These data suggest that budesonide and formoterol inhibit virus-induced inflammatory responses of airway...

  • Effects of Nonsteroidal Anti-Inflammatory Drugs on Experimental Allergic Conjunctivitis in Guinea Pigs. Hashimoto, Terumasa; Igarashi, Atsushi; Hoshina, Futoshi; Yamada, Mie; Toyoda, Yoshihiro; Notsu, Yoshitada; Kohno, Shigekatsu // Journal of Ocular Pharmacology & Therapeutics;Dec2003, Vol. 19 Issue 6, p569 

    The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on experimental allergic conjunctivitis, induced by ocular challenge with antigen in actively sensitized guinea pigs, were investigated. NSAIDs reduced the increase in prostaglandin D[sub 2] (PGD[sub 2]) and E[sub 2] (PGE[sub 2]) in...

  • The effect of the enantiomers of formoterol on inherent and induced tone in guinea-pig trachea and human bronchus. Schmidt, D.; Källström, B.-L.; Waldeck, B.; Branscheid, D.; Magnussen, H.; Rabe, K.F. // Naunyn-Schmiedeberg's Archives of Pharmacology;Apr2000, Vol. 361 Issue 4, p405 

    The long-acting β2-adrenoceptor agonist formoterol is, like all other members of this class of drugs, used as a racemate in the clinic. While the effects of the individual enantiomers have been studied on airway smooth muscle from guinea pig, comparable data on human bronchial smooth muscle...

  • Formoterol, a highly β2-selective agonist, increases energy expenditure and fat utilisation in men. Lee, P; Day, R O; Greenfield, J R; Ho, K K Y // International Journal of Obesity;Apr2013, Vol. 37 Issue 4, p593 

    Background:The sympathetic nervous system regulates energy metabolism via β-adrenoreceptors. Therapeutic exploitation of previous β2-adrenegic agonists for metabolic benefits has been hindered by cross stimulation of cardiac β1-adrenoceptor, causing tachycardia. Formoterol is a novel...

  • A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats. Wex, Eva; Thaler, Eva; Blum, Sylvia; Lamb, David // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Mast cells are central effector cells in allergic asthma and are augmented in the airways of asthma patients. Attenuating mast cell degranulation and with it the early asthmatic response is an important intervention point to inhibit bronchoconstriction, plasma exudation and tissue oedema...

  • Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of E3024, a Novel and Selective Dipeptidyl Peptidase-IV Inhibitor, in Healthy Japanese Male Subjects: Rash Development in Men and Its Possible Mechanism. Yutaka Takeuchi; Masayuki Namiki; Yasumi Kitahara; Setsuo Hasegawa; Akihiro Ohnishi; Nobuyuki Yasuda; Takashi Inoue; Richard Clark; Kazuto Yamazaki // Pharmacology & Pharmacy;Dec2013, Vol. 4 Issue 9, p663 

    E3024 (3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate) is a dipeptidyl peptidase-IV (DPP-IV) inhibitor that was expected to be an antidiabetic agent. Its safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) were investigated in a...

  • Hemodynamic significance of histamine synthesis and histamine H1- and H2-receptor gene expression during endotoxemia. Matsuda, Naoyuki; Hattori, Yuichi; Sakuraya, Fumika; Kobayashi, Masanobu; Zhang, Xiao-Hong; Kemmotsu, Osamu; Gando, Satoshi // Naunyn-Schmiedeberg's Archives of Pharmacology;Dec2002, Vol. 366 Issue 6, p513 

    The hypothesis that endotoxemia may modify histamine synthesis or histamine receptor expression and that these changes may contribute to cardiovascular dysfunction was tested in rabbits which were rendered endotoxemic by lipopolysaccharide (LPS; 100 µg/kg, i.v.). The plasma histamine...

  • Coagulation factors in the airways in moderate and severe asthma and the effect of inhaled steroids. F J H Brims // Thorax;Dec2009, Vol. 64 Issue 12, p1037 

    BACKGROUND: There is evidence of activation of the extrinsic coagulation cascade in the asthmatic airway, and both plasma and locally derived factors may be involved. The hypothesis that the normal haemostatic balance of healthy airways sampled by sputum induction favours fibrin formation in...

  • Leukotriene- and Histamine-Induced Increases in Vascular Permeability and Interstitial Transport in the Skin. Bisgaard, Hans; Lerche, Axel; Kristensen, Johannes K. // Journal of Investigative Dermatology;May85, Vol. 84 Issue 5, p427 

    The aim of the present study was to investigate the edema induced by leukotriene D4 (LTD4). Edema is the gross effect of increased blood flow and capillary permeability. Our objective was to elucidate the effect of LTD4 on edema generation without the influence of the concomitantly increased...


Read the Article


Sign out of this library

Other Topics