Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists

Amrani, Yassine; Panettieri Jr., Reynold A.
January 1998
Thorax;Jan1998, Vol. 53 Issue 1, p713
Academic Journal
No abstract available.


Related Articles

  • Altered CD38/Cyclic ADP-Ribose Signaling Contributes to the Asthmatic Phenotype. Jude, Joseph A.; Dileepan, Mythili; Panettieri Jr., Reynold A.; Walseth, Timothy F.; Kannan, Mathur S. // Journal of Allergy;2012, p1 

    CD38 is a transmembrane glycoprotein expressed in airway smooth muscle cells. The enzymatic activity of CD38 generates cyclic ADP-ribose from β-NAD. Cyclic ADP-ribose mobilizes intracellular calcium during activation of airway smooth muscle cells by G-protein-coupled receptors through...

  • Role of CD38 in Airway Function. Bit Na Kang; Guedes, Alonso G. P.; Tirumurugaan, K. G.; Jude, Joseph A.; Deshpande, Deepak A.; Panettieri, Reynold A.; Amrani, Yassine; Lund, Frances E.; Walseth, Timothy F.; Kannan, Mathur S. // Current Respiratory Medicine Reviews;2006, Vol. 2 Issue 2, p143 

    CD38, a 45-kDa cell surface glycoprotein, is involved in the synthesis of the calcium mobilizing second messenger molecule cyclic ADP-ribose. Cyclic ADP-ribose is known to release calcium from the sarcoplasmic reticulum of airway smooth muscle cells. The pharmacological features of cyclic...

  • PPARγ Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy. Donovan, Chantal; Xiahui Tan; Bourke, Jane Elizabeth // PPAR Research;2012, Special section p1 

    In asthma, the increase in airway smooth muscle (ASM) can contribute to inflammation, airway wall remodeling and airway hyperresponsiveness (AHR). Targetting peroxisome proliferator-activated receptor γ (PPARγ), a receptor upregulated in ASM in asthmatic airways, may provide a novel...

  • Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling. Tang, Dale D. // Respiratory Research;10/30/2015, Vol. 16 Issue 1, p1 

    Asthma is characterized by airway hyperresponsiveness and airway remodeling, which are largely attributed to increased airway smooth muscle contractility and cell proliferation. It is known that both chemical and mechanical stimulation regulates smooth muscle contraction. Recent studies suggest...

  • Airway Smooth Muscle Phenotype and Function: Interactions with Current Asthma Therapies. Halayko, A. J.; Tran, T.; Ji, S. Y.; Yamasaki, A.; Gosens, R. // Current Drug Targets;May2006, Vol. 7 Issue 5, p525 

    Asthma incidence has climbed markedly in the past two decades despite an increased use of medications that suppress airway inflammation and repress contraction of smooth muscle that encircles the airways. Asthmatics exhibit episodes of airway inflammation that potentiates reversible airway...

  • RhoA/Rho-Kinase as a Therapeutic Target in Asthma. Kume, Hiroaki // Current Medicinal Chemistry;2008, Vol. 15 Issue 27, p2876 

    Rho-kinase is an effector molecule of RhoA, a monomeric GTP-binding protein, and causes Ca2+ sensitization via inactivation of myosin phosphatase. The major physiological functions of Rho-kinase include contraction, migration, and proliferation in cells. These actions are thought to be related...

  • IL-17A produced by ?? T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Kudo, Makoto; Melton, Andrew C; Chen, Chun; Engler, Mary B; Huang, Katherine E; Ren, Xin; Wang, Yanli; Bernstein, Xin; Li, John T; Atabai, Kamran; Huang, Xiaozhu; Sheppard, Dean // Nature Medicine;Apr2012, Vol. 18 Issue 4, p547 

    Emerging evidence suggests that the T helper 17 (TH17) subset of ?? T cells contributes to the development of allergic asthma. In this study, we found that mice lacking the ?v?8 integrin on dendritic cells did not generate TH17 cells in the lung and were protected from airway...

  • Effects of Trichloroethylene and Perchloroethylene on Muscle Contractile Responses and Epithelial Prostaglandin Release and Acetylcholinesterase Activity in Swine Trachea. Hwei-Hsien Chen; Yi-Ruu Lin; Quan-Guo Peng; Ming-Huan Chan // Toxicological Sciences;Jan2005, Vol. 83 Issue 1, p149 

    Trichloroethylene (TCE) and perchloroethylene (PERC) have been reported to induce respiratory complications such as airway hyperactivity and asthma. The present study was designed to investigate their influence on smooth muscle contraction and epithelial release of prostanoids in swine trachea....

  • Alteration of airway responsiveness mediated by receptors in ovalbumin-induced asthmatic E3 rats. Jing-wen LONG; Xu-dong YANG; Lei CAO; She-min LU; Yong-xiao CAO // Acta Pharmacologica Sinica;Jul2009, Vol. 30 Issue 7, p965 

    AbstractAim:Airway hyperresponsiveness is a constant feature of asthma. The aim of the present study was to investigate airway hyperreactivity mediated by contractile and dilative receptors in an ovalbumin (OVA)-induced model of rat asthma.Methods:Asthmatic E3 rats were prepared by...

  • A Liver-X-Receptor Ligand, T0901317, Attenuates IgE Production and Airway Remodeling in Chronic Asthma Model of Mice. Shi, Ying; Xu, Xiantao; Tan, Yan; Mao, Shan; Fang, Surong; Gu, Wei // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    The liver-X-receptors have shown anti-inflammatory ability in several animal models of respiratory disease. Our purpose is to investigate the effect of LXR ligand in allergen-induced airway remodeling in mice. Ovalbumin-sensitized mice were chronically challenged with aerosolized ovalbumin for 8...


Read the Article


Sign out of this library

Other Topics