TITLE

Allelic variants of polymorphic genes associated with a higher frequency of chromosome aberrations

AUTHOR(S)
Sal'nikova, L.; Chumachenko, A.; Lapteva, N.; Vesnina, I.; Kuznetsova, G.; Rubanovich, A.
PUB. DATE
November 2011
SOURCE
Russian Journal of Genetics;Nov2011, Vol. 47 Issue 11, p1364
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Genotypic associations were studied for the frequency of chromosome aberrations in human peripheral blood lymphocytes. Cytogenetic analysis (1000 metaphase plate per individual) and genotyping at 19 sites of genes involved in detoxification and DNA repair were performed in a sample of 83 Chernobyl liquidators and a matched control sample of 96 volunteers. In either sample, the frequency of chromosome aberrations was higher in carriers of the minor alleles of the XPD gene (sites 2251T > G and 862G > A) and the positive genotypes of the GSTM1- GSTT1 genes. The highest frequency of chromosome aberrations was observed in carriers of a combined genotype including at least one minor allele of the XPD sites + at least one insertion in the GSTM1-GSTT1 genes. The high-risk genotype, which had a prevalence of 64%, was strongly associated with a higher frequency of chromosome aberrations in both volunteers (OR = 6.9, p = 0.008) and Chernobyl liquidators (OR = 5.6, p = 0.002).
ACCESSION #
67105236

 

Related Articles

  • Association of MTHFR polymorphisms and chromosomal abnormalities in leukemia. Sinthuwiwat, Thivaratana; Poowasanpetch, Phanasit; Wongngamrungroj, Angsana; Soonklang, Kamonwan; Promso, Somying; Auewarakul, Chirayu; Tocharoentanaphol, Chintana // Disease Markers;2012, Vol. 32 Issue 2, p115 

    Genetic variation in MTHFR gene might explain the interindividual differences in the reduction of DNA repaired and the increase of chromosome breakage and damage. Nowadays, chromosomal rearrangement is recognized as a major cause of lymphoid malignancies. In addition, the association of MTHFR...

  • Cytogenetic study of hemopoietic stem cells. Bitov, Nurzat T.; Nakhanov, Aziz K.; Ibraimova, Nikar M.; Mamadaliyev, Seidigapbar M.; Sharipov, Islamgali K.; Bolegenova, Nazym K.; Djansugurova, Leyla B. // Agriculture & Biology Journal of North America;2010, Vol. 1 Issue 2, p124 

    The paper presents the results of cytogenetic and molecular-genetic studies of primary and continuous cultures of human hemopoietic stem cells (HSC) with assessment of their genetic stability. Frequency analysis of structural (chromosomal aberrations) and genomic (in aneuploid and polyploid...

  • Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects. Vodicka, Pavel; Musak, Ludovit; Frank, Christoph; Kazimirova, Alena; Vymetalkova, Veronika; Barancokova, Magdalena; Smolkova, Bozena; Dzupinkova, Zuzana; Jiraskova, Katerina; Vodenkova, Sona; Kroupa, Michal; Osina, Oto; Naccarati, Alessio; Palitti, Fabrizio; Försti, Asta; Dusinska, Maria; Vodickova, Ludmila; Hemminki, Kari // Carcinogenesis;Nov2015, Vol. 36 Issue 11, p1299 

    Human cancers are often associated with numerical and structural chromosomal instability. Structural chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBL) arise as consequences of direct DNA damage or due to replication on a damaged DNA template. In both cases, DNA repair is...

  • UGT1A1*28 Polymorphism in Chronic Lymphocytic Leukemia: The First Investigation of the Polymorphism in Disease Susceptibility and Its Specific Cytogenetic Abnormalities. Karakosta, Maria; Kalotychou, Vassiliki; Kostakis, alkiviadis; Pantelias, Gabriel; Rombos, Ioannis; Kouraklis, Gregory; Manola, Kalliopi N. // Acta Haematologica;Jun2014, Vol. 132 Issue 1, p59 

    Chronic lymphocytic leukemia (CLL) has been recently attributed to a combination of genetic predisposition and exposure to environmental factors. UDP-glucuronosyltransferase (UGT)1A1*28 is an inborn polymorphism that results in significant downregulation of uridine diphosphate...

  • Cytogenetic Follow-Up in Testicular Seminoma Patients Exposed to Adjuvant Radiotherapy.  // Collegium Antropologicum;Jun2010, Vol. 34 Issue 2, p455 

    No abstract available.

  • Directly transmitted unbalanced chromosome abnormalities and euchromatic variants. Barber, J. C. K. // Journal of Medical Genetics;Aug2005, Vol. 42 Issue 8, p609 

    In total, 200 families were reviewed with directly transmitted, cytogenetically visible unbalanced chromosome abnormalities (USCAs) or euchromatic variants (EVs). Both the 130 UBCA and 70 EV families were divided into three groups depending on the presence or absence of an abnormal phenotype in...

  • Complex interchanges as a complex function of chromosome organisation. Eidelman, Y. A.; Andreev, S. G. // Radiation Protection Dosimetry;Feb2011, Vol. 143 Issue 2-4, p202 

    A Monte Carlo technique was developed for biophysical modelling of structural organisation of 46 chromosomes within human lymphocyte interphase nucleus. The technique takes into account: different levels of chromatin organisation, non-random localisation of particular chromosomes and chromosome...

  • Crytogenetic Markers, DNA Single-Strand Breaks, Urinary Metabolites, and DNA Repair Rates in Styrene-Exposed Lamination Workers. Vodicka, Pavel; Tuimala, Jarno; Stetina, Rudolf; Kumar, Rajiv; Manini, Paola; Naccarati, Alessio; Maestri, Luciano; Vodickova, Ludmila; Kuricova, Miroslava; Jäventaus, Hilkka; Majvaldova, Zuzana; Hirvonen, Ari; Imbriani, Marcello; Mutti, Antonio; Migliore, Lucia; Norppa, Hannu; Hemminki, Kari // Environmental Health Perspectives;Jun2004, Vol. 112 Issue 8, p867 

    The effect of occupational exposure to styrene on frequencies of chromosomal aberrations and binucleated cells with micronuclei and on single-strand break levels in peripheral blood lymphocytes was studied in 86 reinforced plastic workers and 42 control individuals (including 16 maintenance...

  • Genotoxic Monitoring of Workers at a Hazardous Waste Disposal Site in Mexico. Gonsebatt, Maria E.; Salazar, Ana M.; Montero, Regina; Ostrosky-Wegman, Patricia; Barriga, Fernando Diaz; Yanez, Leticia; Gomez, Humberto // Environmental Health Perspectives Supplements;Feb95 Supplement 1, Vol. 103, p111 

    Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics