Improving self-report measures of medication non-adherence using a cheating detection extension of the randomised-response-technique

Ostapczuk, Martin; Musch, Jochen; Moshagen, Morten
October 2011
Statistical Methods in Medical Research;Oct2011, Vol. 20 Issue 5, p489
Academic Journal
Medication non-adherence is a serious problem for medical research and clinical practice. Self-reports are only moderately valid, and objective methods are cumbersome and expensive to administer. We sought to improve self-reports of medication non-adherence using a cheating detection extension of the randomised-response-technique (RRT). This RRT variant encourages more honest responses by offering interviewees a higher degree of anonymity while simultaneously allowing us to estimate the proportion of respondents disobeying the RRT instructions. The 597 patients were asked to report their lifetime prevalence of medication non-adherence under one of two different questioning procedures, direct questioning or randomised-response. When questioned directly, only 20.9% of patients admitted to intentional medication non-adherent behaviour, as opposed to 32.7% of patients under RRT conditions. Additionally, the cheating detection extension revealed a significant proportion of patients (47.1%) disobeying the instructions in the RRT condition. Assuming that either none or all of them were non-adherent, a lower and upper bound of 32.7% and 79.8%, respectively, could be estimated for the lifetime prevalence of non-adherent behaviour. The results demonstrate that self-report measures as well as traditional variants of the RRT, which do not take cheating into account, may provide considerably distorted estimates of the prevalence of medication non-adherence.


Related Articles

  • Assessing medication adherence: options to consider. Lehmann, Audrey; Aslani, Parisa; Ahmed, Rana; Celio, Jennifer; Gauchet, Aurelie; Bedouch, Pierrick; Bugnon, Olivier; Allenet, BenoĆ®t; Schneider, Marie // International Journal of Clinical Pharmacy;Feb2014, Vol. 36 Issue 1, p55 

    Background Adherence to chronic therapy is a key determinant of patient health outcomes in chronic disease. However, only about 50 % of patients adhere to chronic therapy. One of the challenges in promoting adherence is having an accurate understanding of adherence rates and the factors that...

  • Research Nurses and Good Clinical Practice. Hill, Marcia J. // Dermatology Nursing;Dec2002, Vol. 14 Issue 6, p359 

    Deals with clinical practice guidelines for research nurses. Responsibilities common to all clinical practice guidelines; Mechanism of selecting human subjects for research; Importance of obtaining informed consent of the patient to research nurses; Safeguards for conducting medical research.

  • Thank God for noncompliance--this time, at least. Peterson, Kerri M. // Medical Economics;05/21/2001, Vol. 78 Issue 10, p111 

    Discusses the experience of a physician in dealing with an aged patient on multiple medications. Confusion brought by the generic names and brand names of drugs; Failure of the patient to complete his antibiotic medications; Significance of developing a system to avoid confusion; Ways by which...

  • Compliance and Persistence in Pediatric and Adult Patients Receiving Growth Hormone Therapy. Ron Rosenfeld; Bert Bakker // Endocrine Practice;Mar2008, Vol. 14 Issue 2, p143 

    Objective: To identify key factors that influence compliance and persistence in patients receiving growth hormone (GH) therapy and to promote the development of interventions to support continuous GH use.Methods: A 134-question survey was conducted involving 158 adult patients, 326 adolescents...

  • Multiple self-report measures of antiretroviral adherence correlated in Sierra Leone, but did they agree? Kelly, J Daniel; Hubenthal, Erica A; Lurton, Gregoire; Empson, Susannah F; Barrie, M Bailor; Kargbo, Brima; Wagner, Glenn J; Giordano, Thomas P // International Journal of STD & AIDS;Dec2013, Vol. 24 Issue 12, p931 

    In resource-poor settings, studies validating multiple self-report measures of adherence are limited and do not include data from West Africa. We prospectively assessed the associations between multiple self-report measures of adherence in 58 patients receiving antiretroviral therapy....

  • Second-generation antipsychotic AE monitoring adequate?  // PharmacoEconomics & Outcomes News;3/31/2012, Issue 650, p9 

    The article reports on a study which found that there is a limited adherence to suggested cardiometabolic adverse event (AE) monitoring guidelines in patients receiving second-generation antipsychotics.

  • From JAMA's Daily News Site.  // JAMA: Journal of the American Medical Association;11/14/2012, Vol. 308 Issue 18, p1848 

    The article offers news briefs related medical research discoveries in the U.S. on topics including consumption of Vitamin D by healthy adults, patients' adherence to medication who read their physicians' notes online, and the association of prison brew with botulism outbreak.

  • Improved adherence with once-daily versus twice-daily dosing of mometasone furoate administered via a dry powder inhaler: a randomized open-label study. Price, David; Robertson, Anne; Bullen, Kevin; Rand, Cynthia; Horne, Rob; Staudinger, Heribert // BMC Pulmonary Medicine;2010, Vol. 10, p1 

    Background: Poor adherence with prescribed asthma medication is a major barrier to positive treatment outcomes. This study was designed to determine the effect of a once-daily administration of mometasone furoate administered via a dry powder inhaler (MF-DPI) on treatment adherence compared with...

  • FLOATING GASTRO-RETENTIVE DOSAGE FORMS - A NOVEL APPROACH FOR TARGETED AND CONTROLLED DRUG DELIVERY. Aleksovski, Aleksandar // Human: Journal for Interdisciplinary Studies;2012, Vol. 2 Issue 1, p23 

    Controlled (modified) release dosage forms are one of the key concepts in drug delivery, leading to enhanced drug bioavailability and increased patient's compliance. However conventional modified release dosage forms encounter one big disadvantage- lack of site-specific drug delivery. Scientists...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics