Structural studies of the PARP-1 BRCT domain

January 2011
BMC Structural Biology;2011, Vol. 11 Issue 1, p37
Academic Journal
The article explains the solution structure and biophysical characterization of the BRCT domain of rat Poly(ADP-ribose) polymerase-1 (PARP-1). It is mentioned that the PARP-1 BRCT has the conserved BRCT fold, protein interaction module in DNA repair and cell signalling pathways. It is also indicated that a poly(ADP-ribose)-dependent mechanism for localization of XRCC1 to sites of DNA damage.


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