Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study

January 2011
BMC Public Health;2011, Vol. 11 Issue 1, p733
Academic Journal
The article presents the findings of a population-based CoLaus study which reports that hyperhomocysteinemia is independently associated with albuminuria. It examines whether homocysteine and uric acid are associated with glomerular filtration rate (GFR) and albuminuria independently of each other. It concludes that in general adult population, elevated serum homocysteine and uric acid are associated with albuminuria independently of each other and of renal function.


Related Articles

  • Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: The Tromsø Study. Storhaug, Hilde M.; Toft, Ingrid; Norvik, Jon Viljar; Jenssen, Trond; Eriksen, Bjørn O.; Melsom, Toralf; Løchen, Maja-Lisa; Solbu, Marit Dahl // BMC Nephrology;12/11/2015, Vol. 16, p1 

    Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome...

  • Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. WOLLESEN, FLEMMING; BRATTSTRÖM, LARS; REFSUM, HELGA; UELAND, PER M.; BERGLUND, LARS; BERNE, CHRISTIAN; Wollesen, Flemming // Kidney International;Mar1999, Vol. 55 Issue 3, p1028 

    Plasma total homocysteine and cysteine in relation to glomerular filtration rate in diabetes mellitus. Background. The plasma concentrations of total homocysteine (tHcy) and total cysteine (tCys) are determined by intracellular metabolism and by renal plasma clearance, and we hypothesized that...

  • The diverse associations of uric acid with low-grade inflammation, adiponectin and arterial stiffness in never-treated hypertensives. Tsioufis, C.; Kyvelou, S.; Dimitriadis, K.; Syrseloudis, D.; Sideris, S.; Skiadas, I.; Katsi, V.; Stefanadi, E.; Lalos, S.; Mihas, C.; Poulakis, M.; Stefanadis, C. // Journal of Human Hypertension;Sep2011, Vol. 25 Issue 9, p554 

    The data regarding the role of serum uric acid (SUA) along with subclinical inflammation in the context of hypertensive vascular damage are rather scarce and controversial. Towards this end, we assess the links between SUA, high-sensitivity CRP (hs-CRP), adiponectin and carotid to femoral pulse...

  • Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy. Jingjing Zhou; Yuqing Chen; Ying Liu; Sufang Shi; Xueying Li; Suxia Wang; Hong Zhang // BMC Nephrology;2014, Vol. 15 Issue 1, p1 

    Background Hyperuricemia appeared to be a common symptom in IgA nephropathy (IgAN), even in those with normal eGFR. IgAN was characterized by variation of pathological features, especially variable tubulointerstitial lesions. Since tubular reabsorption and excretion appeared to be more important...

  • Low glomerular filtration in the population: Prevalence, associated disorders, and awareness. Cirillo, M.; Laurenzi, M.; Mancini, M.; Zanchetti, A.; Lombardi, C.; de Santo, N. G. // Kidney International;Aug2006, Vol. 70 Issue 4, p800 

    Estimated glomerular filtration rate (eGFR) was used for analysis of kidney disease prevalence in the United States. The study investigated on prevalence, associated disorders, and kidney disease awareness in an Italian population sample. Data were collected on serum creatinine, other laboratory...

  • Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function. Toyama, Tadashi; Furuichi, Kengo; Shimizu, Miho; Hara, Akinori; Iwata, Yasunori; Sakai, Norihiko; Perkovic, Vlado; Kobayashi, Makoto; Mano, Toshiki; Kaneko, Shuichi; Wada, Takashi // PLoS ONE;9/10/2015, Vol. 10 Issue 9, p1 

    Background: Some observational studies have shown the relationships between hyperuricemia and chronic kidney disease (CKD); however, the threshold of serum uric acid (SUA) for deterioration of kidney function and the association between SUA and kidney injury by baseline kidney function remains...

  • Epithelial-to-mesenchymal transition in podocytes mediated by activation of NADPH oxidase in hyperhomocysteinemia. Zhang, Chun; Xia, Min; Boini, Krishna; Li, Cai-Xia; Abais, Justine; Li, Xiao-Xue; Laperle, Laura; Li, Pin-Lan // Pflugers Archiv European Journal of Physiology;Sep2011, Vol. 462 Issue 3, p455 

    The present study tested the hypothesis that hyperhomocysteinemia (hHcys) induces podocytes to undergo epithelial-to-mesenchymal transition (EMT) through the activation of NADPH oxidase (Nox). It was found that increased homocysteine (Hcys) level suppressed the expression of slit...

  • CKD: Consistency of GFR and Albuminuria as Risk Predictors. Kuritzky, Louis // Neurology Alert;Mar2013 Clinical Briefs in Primary Care, p6 

    The article discusses research on the use of glomerular filtration rate (GFR) and albuminuria as predictors of chronic kidney disease (CKD), referencing a study by S. I.Hallan and colleagues, published in the "Journal of the American Medical Association."

  • Microalbuminuria Predicts GFR in Hypertensive NIDDM Patients.  // Kidney;Mar/Apr98, Vol. 7 Issue 2, p63 

    Discusses the abstract of the article 'Microalbuminuria as a predictor of a drop in glomerular filtration rate in subjects with non-insulin-dependent diabetes mellitus and hypertension,' by G. Berrut, B. Bouhanick et al, published in the 1997 issue of the 'Clinical Nephrology' journal.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics