TITLE

Lorcaserin: An investigational serotonin 2C agonist for weight loss

AUTHOR(S)
HURREN, KATHRYN M.; BERLIE, HELEN D.
PUB. DATE
November 2011
SOURCE
American Journal of Health-System Pharmacy;11/1/2011, Vol. 68 Issue 21, p2029
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose. The pharmacology, pharmacokinetics, and adverse effects of the selective serotonin (5-HT) agonist lorcaserin are reviewed, with an emphasis on efficacy and safety data from Phase III clinical trials. Summary. Lorcaserin is highly selective for a subtype of 5-HT receptors important in appetite regulation, with low affinity for other 5-HT-receptor subtypes whose activation is thought to underlie serious cardiovascular adverse effects; such effects have been seen with nonselective serotonergic agents for weight loss (e.g., fenfluramine). In two Phase III trials of lorcaserin, the cumulative proportion of patients who achieved weight loss of ≥5% over 12 months was about 47% with lorcaserin use versus 20-5% among placebo users (p < 0.0001 for both trials). Lorcaserin was generally well tolerated in the clinical trials to date; nausea and vomiting, headache, and dizziness were the most commonly reported adverse effects. In two of the three Phase III trials to date, lorcaserin use was not found to increase the risk of cardiac valvulopathy; however, in the other Phase III trial, which focused on patients with diabetes, lorcaserin use was associated with an increased rate of new valvulopathy. In a carcinogenicity evaluation involving laboratory rats, lorcaserin was linked to the development of various malignancies, a finding with uncertain implications for its potential future use in humans. Conclusion. Lorcaserin, a 5-HT2C agonist, has demonstrated efficacy in patients who are obese or are overweight with associated comorbidities. Phase III trials have found that more than 35% of patients lost greater than 5% of their baseline weight. The maker of lorcaserin has indicated it will continue to seek U.S. marketing approval of the drug for the indications of long-term weight loss and weight-loss maintenance in specific patient populations.
ACCESSION #
66907938

 

Related Articles

  • Lorcaserin: a guide to its use in chronic weight management. Lyseng-Williamson, Katherine; Hoy, Sheridan // Drugs & Therapy Perspectives;Oct2013, Vol. 29 Issue 10, p303 

    Oral lorcaserin (Belviq), a novel selective serotonin 5-HT receptor agonist, is indicated in the USA as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management of obese adults, or overweight adults with at least one weight-related co-morbidity. In...

  • Pharmacologic interventions for weight-related health risks. BAYS, HAROLD E.; BILLES, SONJA K. // Clinical Advisor;Oct2014, Vol. 17 Issue 10, p51 

    No abstract available.

  • Lorcaserin Hydrochloride. Cada, Dennis J.; Levien, Terri L.; Baker, Danial E. // Hospital Pharmacy;Nov2012, Vol. 47 Issue 11, p871 

    The article discusses the new drug Lorcaserin Hydrochloride with the proprietary name Belviq (Arena/Eisai), which is used as an adjunct to a reduced calorie diet and increased physical activity for long-term weight management in adult patients with a body mass index (BMI) of 30 kg/m2 or greater...

  • Drug Treatment of Obesity in Cardiovascular Disease. Charakida, Marietta; Finer, Nicholas // American Journal of Cardiovascular Drugs;2012, Vol. 12 Issue 2, p93 

    Obesity is a significant health problem worldwide and is associated with a number of co-morbidities including type 2 diabetes mellitus, hypertension, dyslipidemia, obstructive sleep apnea, and cardiovascular disease. A number of different pathophysiologic mechanisms including increased...

  • Weight-loss Drug Effective Without Cardiac Side Effects? Elliott, William T. // Clinical Cardiology Alert;Sep2010 Clinical Briefs, p1 

    The article discusses the results of a study of lorcaserin, a selective 2C-receptor agonist from Arena Pharmaceuticals which has filed for a new drug application with the U.S. Food and Drug Administration (FDA). The phase III trial found that the medication causes weight loss without cardiac...

  • CHECK OUT. weight loss: 3 ways. Tweed, Vera // Better Nutrition;Jan2012, Vol. 74 Issue 1, p18 

    The article discusses three dietary supplements. African mango extract can reduce body fat and total cholesterol. The hormone human chorionic gonadotropin (hCG) triggers fat burning when combined with a very-low-calorie diet. Polyglycoplex (PGX) is a fiber that expands when combined with...

  • High demand likely for prescription weight-control drugs.  // Mayo Clinic Health Letter;Nov2012, Vol. 30 Issue 11, p4 

    The article reports that recent approval of two weight control drugs by the US Food and Drug Administration (FDA) is fueling renewed interest in medication-based weight loss. The new prescription drugs Belviq and Qsymia are the first weight-control drugs in 13 years to receive FDA approval....

  • POSTTEST.  // Clinical Advisor;Oct2014, Vol. 17 Issue 10, p59 

    No abstract available.

  • Obesity medications reduce total body weight by 3–9% compared with placebo, when combined with lifestyle changes. Gadde, Kishore M.; Yancy Jr., William S. // Evidence Based Nursing;Jan2015, Vol. 18 Issue 1, p29 

    The article discusses the study on the use of pharmacotherapy on obese people for the achievement of weight loss to prevent complications such as type 2 diabetes and coronary artery disease. The study involves published literature for randomised controlled trials (RCTs) and meta-analyses that...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics