TITLE

Muscarinic blockade of methacholine induced airway and parenchymal lung responses in anaesthetised rats

AUTHOR(S)
Tulić, M. K.; Wale, J. L.; Peták, F.; Sly, P. D.
PUB. DATE
June 1999
SOURCE
Thorax;Jun1999, p531
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
66877122

 

Related Articles

  • Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response. Castro, Juciane Maria De Andrade; Resende, Rodrigo R.; Mirotti, Luciana; Florsheim, Esther; Albuquerque, Layra Lucy; Lino-Dos-Santos-Franco, Adriana; Gomes, Eliane; De Lima, Wothan Tavares; De Franco, Marcelo; Ribeiro, Orlando Garcia; Russo, Momtchilo // BioMed Research International;2013, p1 

    Airway smooth muscle constriction induced by cholinergic agonists such as methacholine (MCh), which is typically increased in asthmatic patients, is regulated mainly by muscle muscarinic M3 receptors and negatively by vagal muscarinic M2 receptors. Here we evaluated basal (intrinsic) and...

  • Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response. de Andrade Castro, Juciane Maria; Resende, Rodrigo R.; Mirotti, Luciana; Florsheim, Esther; Albuquerque, Layra Lucy; Lino-dos-Santos-Franco, Adriana; Gomes, Eliane; de Lima, Wothan Tavares; de Franco, Marcelo; Ribeiro, Orlando Garcia; Russo, Momtchilo // BioMed Research International;2013, Vol. 2013, p1 

    Airway smooth muscle constriction induced by cholinergic agonists such as methacholine (MCh), which is typically increased in asthmatic patients, is regulated mainly by muscle muscarinic M3 receptors and negatively by vagal muscarinic M2 receptors. Here we evaluated basal (intrinsic) and...

  • Differential Effects of Allergen Challenge on Large and Small Airway Reactivity in Mice. Donovan, Chantal; Royce, Simon G.; Esposito, James; Tran, Jenny; Ibrahim, Zaridatul Aini; Tang, Mimi L. K.; Bailey, Simon; Bourke, Jane E. // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to be fully assessed. This study used a mouse model of chronic allergic airways disease to induce inflammation and remodelling and determine whether in vivo hyperresponsiveness to methacholine is...

  • Deep Inhalation and Airway Patency in Children. Marchal, François; Schweitzer, Cyril // Current Pediatric Reviews;2006, Vol. 2 Issue 4, p339 

    Deep inhalation (DI) induces changes in airway calibre that may last beyond the manoeuvre itself. The mechanisms involve mechanical interaction between conducting airways subjected to parenchymal tethering and lung parenchyma itself. Healthy children usually show small bronchodilation after DI....

  • Long Term Cigarette Smoke Exposure Does Not Increase Airway Responsiveness in Rats. Wright, J.L.; Sun, J.-P.; Vedal, S. // Lung;1998, Vol. 176 Issue 4, p289 

    Examines the effect chronic cigarette smoke exposure on airway responsiveness using methacholine response tests in Sprague-Dawley rats. Calculation of pulmonary resistance after nebulization of saline and methacholine; Association between methacholine sensitivity and muscle inflammation;...

  • Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle. Oenema, Tjitske A.; Kolahian, Saeed; Nanninga, Janke E.; Rieks, Daniëlle; Hiemstra, Pieter S.; Zuyderduyn, Suzanne; Halayko, Andrew J.; Meurs, Herman; Gosens, Reinoud // Respiratory Research;2010, Vol. 11, p130 

    Background: Acetylcholine, the primary parasympathetic neurotransmitter in the airways, plays an important role in bronchoconstriction and mucus production. Recently, it has been shown that acetylcholine, by acting on muscarinic receptors, is also involved in airway inflammation and remodelling....

  • Effet of Combined Nitrogen Dioxide and Carbon Nanoparticle Exposure on Lung Function During Ovalbumin Sensitization in Brown Norway Rat. Layachi, Skander; Rogerieux, Françoise; Robidel, Franck; Lacroix, Ghislaine; Bayat, Sam; Kalinichenko, Vladimir V. // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    The interaction of particulate and gaseous pollutants in their effects on the severity of allergic inflammation and airway responsiveness are not well understood. We assessed the effect of exposure to NO2 in the presence or absence of repetitive treatment with carbon nanoparticle (CNP) during...

  • Organophosphorus Insecticides Induce Airway Hyperreactivity by Decreasing Neuronal M2 Muscarinic Receptor Function Independent of Acetylcholinesterase Inhibition. Lein, Pamela J.; Fryer, Allison D. // Toxicological Sciences;Jan2005, Vol. 83 Issue 1, p166 

    We previously demonstrated that the organophosphorus (OP) insecticide chlorpyrifos potentiates vagally induced bronchoconstriction independent of acetylcholinesterase (AChE) inhibition by decreasing the function of neuronal M2 muscarinic receptors that normally inhibit acetylcholine release from...

  • The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose. Zosky, Graeme R.; Von Garnier, Christophe; Stumbles, Philip A.; Holt, Patrick G.; Sly, Peter D.; Turner, Debra J. // Respiratory Research;2004, Vol. 5, p15 

    Background: Considerable variation exists in the protocols used to induce hyperresponsiveness in murine models of allergic sensitisation. We examined the effect of varying the number of antigen exposures at challenge on the development of methacholine responsiveness in systemically sensitised...

  • Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat. Aronsson, Patrik; Vesela, Renata; Johnsson, Martin; Tayem, Yasin; Wsol, Vladimir; Winder, Michael; Tobin, Gunnar // BioMed Research International;2014, Vol. 2014, p1 

    Nitric oxide (NO) has pivotal roles in cyclophosphamide- (CYP-) induced cystitis during which mucosal nitric oxide synthase (NOS) and muscarinic M5 receptor expressions are upregulated. In cystitis, urothelial muscarinic NO-linked effects hamper contractility. Therefore we wondered if a blockade...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics