TITLE

Relationships between antithrombin activity, anticoagulant efficacy of heparin therapy and perioperative variables in patients undergoing cardiac surgery requiring cardiopulmonary bypass

AUTHOR(S)
Muedra, V; Bonanad, S; Gómez, M; Villalonga, V; Sánchez, F; Llopis, J E
PUB. DATE
November 2011
SOURCE
Perfusion;Nov2011, Vol. 26 Issue 6, p487
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: A study on 149 cardiopulmonary bypass (CPB) patients was performed to elucidate possible relationships between antithrombin (AT) activity and a subject’s clinical profile or surgery characteristics.Methods: An initial dose (300 IU/kg) of heparin was administered before CPB. Additional boluses (100 IU/kg) were administered if the activated clotting time (ACT)≤460 s. AT activity and hematological parameters were determined preoperatively, during and after CPB, and at 12, 24, 36, and 48 hours post-intervention.Results: 29.5% patients required an additional dose of heparin during CPB. Preoperative AT was 96.5 ± 13.9% in all but 4 patients. AT was significantly lower during CPB and upon leaving the operating room (59.7%-80.0%). A small, but significant, inverse correlation was observed between AT at the end of CPB and the patient’s age, as well as between basal preoperative AT and total heparin administered.Conclusions: Patient’s age could be a moderate indicator of AT activity drop and low preoperative AT activity could be a sign of reduced anticoagulant efficacy of heparin during CPB.
ACCESSION #
66820233

 

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